Registration Dossier
Registration Dossier
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EC number: 231-512-4 | CAS number: 7601-90-3
Endpoint summary
Administrative data
Description of key information
Additional information
READ-ACROSS JUSTIFICATION
When ecotoxicity data required by REACH regulation are missing for perchloric acid, a read-across approach with Sodium perchlorate (CAS RN: 7601-89-0) and Sodium perchlorate monohydrate (CAS RN: 7791 -07 -3) is performed. This approach is justified by the information below:
1) Structural similarity
Sodium perchlorate is the sodium salt of perchloric acid. Therefore, they have similar chemical structure.
2) Similar bioavailability
Both substances are very soluble in water. In the aquatic environment, sodium perchlorate dissociates into perchlorate anion (ClO4-) and Na+. As perchloric acid is a strong acid, it is completely dissociated into aquatic environment and it is neutralized by the cations present in the natural environment, including Na+. Therefore, the bioavailability of the perchlorate moiety should be the same for both substances.
Additionally, as both substances are inorganic, biodegradability is not applicable.
Based on the above information, both substances should show similar bioavailability to organisms in the environment, similar distribution between the environmental compartments and similar fate in the environment.
3) Similar ecotoxicity potential
Data on aquatic toxicity of perchloric acid is only available for Daphnids. The 48-hour EC50 forDaphnia magnais >100 mg/L (Study performed in 2004, the pH of test solution has been neutralised) and no immobility has been observed in this study. This result is in line with available data on sodium perchlorate showing no acute toxicity to aquatic invertebrates.
As sodium is not toxic to the aquatic organisms, and as physical effect due to acidity is not taken into account to determine the PNEC and the classification of the substance, the toxicity effect of perchloric acid and sodium perchlorate is due to the activity of the perchlorate moiety. This supports the fact that both substances should show similar effect on organisms.
To conclude, based on the similar chemical structure, bioavailability and ecotoxicity potential, the ecotoxicity data and environmental fate and behavior information obtained on sodium perchlorate can be used to assess the environmental profile of perchloric acid. There are plenty of data on sodium perchlorate and a REACH registration dossier is available. In order to avoid describing all data and information on sodium perchlorate, the strategy of selection of data is explained in the endpoint study summary of each concerned endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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