Registration Dossier
Registration Dossier
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EC number: 231-512-4 | CAS number: 7601-90-3
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
Description of key information
Perchloric acid is not bioaccumulable in aquatic organisms tested.
Key value for chemical safety assessment
- BCF (aquatic species):
- 0.14 L/kg ww
Additional information
One reliable key study (Liu et al., 2006) is available on the bioaccumulative potential of sodium perchlorate in fish. This study was performed with a method comparable to study guideline, without GLP statement, but with acceptable restrictions, to assess the uptake, accumulation and depuration of sodium perchlorate in zebrafish (Danio rerio).
Zebrafish were exposed to two concentrations of sodium perchlorate (10 and 100 mg/L) for 90 days. The uptake and accumulation by zebrafish was evaluated at 10, 30, 60 and 90 days. In addition, depuration was examined at 1, 3 and 5 days after cessation of the exposure.
Two methods can be used to determine the BCF values:
- BCF based on the ratio of concentration in the fish and in the water at apparent steady-state: the whole body BCFs were 0.12 -0.14 and 0.09 -0.11 L/kg in fish exposed to 10 and 100 mg/L sodium perchlorate, respectively.
- BCF based on the ratio of the rate constants of uptake and depuration assuming first-order kinetics: the highest BCF was 0.039 in fish exposed to 100 mg/L sodium perchlorate. The BCF value at 10 mg/L cannot be determined because due to accidental contamination of fish samples from 10 mg/L sodium perchlorate treatment at day 10 and 30, no uptake constants were determined for this treatment.
The steady-state was reached by day 10.
With the highest BCF values of 0.14 L/kg and 0.11 L/kg at exposure of 10mg/L and 100 mg/L respectively, it appears that the BCF is not dependent to the tested concentration. Considering this low BCF values and the rapid depuration of perchlorate observed in zebrafish, perchlorate is considered as non bioaccumulative.
Published supporting studies are reported in the REACH dossier of sodium perchlorate. All of these studies support the low bioaccumulative potential of perchlorate.
Two published studies of Dean et al., 2004, are also described as supporting studies in the present dossier. These studies are described in iuclid because the paper of Dean et al., 2004, is used as key study for fish acute toxicity endpoint. To submit a consistent dossier, it was considered important to report all the endpoints covered in this paper. The two bioaccumulation studies reported by Dean et al., 2004, were selected as supporting studies because the BCF values reported are low. But they were considered as not reliable because only the uptake phase was performed and no information was mentioned if a steady-state was achieved or not.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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