Registration Dossier
Registration Dossier
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EC number: 214-093-2 | CAS number: 1079-66-9
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
According to the results of the study, the test substance did not lead to an relevant increase in the number of revertant colonies either without S9 mix or after adding a metabolizing system in several experiments carried out independently of each other (standard plate test and preincubation assay). However, the increase in the number of his+ revertants observed in the preincubation test with the test strain TA 100 was not reproduced in a repeat experiment, and so these findings have to be regarded as biological irrelevant. Besides, the results of the negative as well as the positive controls performed in parallel corroborated the validity of this study, since the values fulfilled the acceptance criteria of this study.
In this study with and without S9 mix, the number of revertant colonies in the negative controls was within the range of the historical negative control data for each tester strain.
In addition, the positive control substances both with and without S9 mix induced a significant increase in the number of revertant colonies within the range of the historical positive control data or above. [BASF, 2013]
Short description of key information:
Chlorodiphenylphosphine is not a mutagenic test substance in the bacterial reverse mutation test in the absence and the presence of metabolic activation. [BASF, 2013]
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
The available information is considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified as mutagenic under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.
Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008
The available information is considered reliable and suitable for classification purposes under 67/548/EEC. As a result the substance is not considered to be classified as mutagenic under Regulation (EC) No. 1272/2008, as amended for the second time in Directive (EC 286/2011).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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