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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1973
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
Secondary information from a study in rats, performed in 1973, taken from public TSCA8e submission file. Study was not performed according to GLP, but test parameters documented are sufficient to accept the data, which are well documented and scientifically acceptable.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1973
Report date:
1973

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Primary skin irritation was determined according to the proposed FDA revision of the test for primary skin irritants published in the Federal Register 37, no. 244, Dec. 19, 1972. This procedure is described in Appendix A.
The proposed test differs from the procedure described in the Hazardous Substances Labelling Act, Part 191.11, Chapter, Title 21 in that irritation is determined after a 4-hour exposure period rather than after the proviously required 24-hour exposure period. In the proposed test, readings are made 4, 24, and 48 hours after treatment. Animals are to be retained for observation 96 hours after initial application. Any delayed necrosis will be reported, but the data will not be used in determination of irritation indices. A corrosive substance is defined as a material that causes tissue destruction within 48 hours after application on any of the six intact sites with or without similar destruction on the abraded areas.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Chlorodiphenylphosphine
EC Number:
214-093-2
EC Name:
Chlorodiphenylphosphine
Cas Number:
1079-66-9
Molecular formula:
C12H10ClP
IUPAC Name:
diphenylphosphinous chloride
Details on test material:
clear colorless diphenyl phosphinous chloride

Test animals

Species:
rabbit

Test system

Type of coverage:
occlusive
Vehicle:
unchanged (no vehicle)
Controls:
no
Duration of treatment / exposure:
4 hours
Observation period:
96 hours
Number of animals:
6

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Remarks:
animals 1-6
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible
Irritation parameter:
edema score
Basis:
mean
Remarks:
animals 1-6
Time point:
24/48 h
Score:
4
Max. score:
4
Reversibility:
not reversible

Any other information on results incl. tables

All test rabbits exhibited extensive eschar with severe edema.

Applicant's summary and conclusion

Interpretation of results:
Category 1B (corrosive) based on GHS criteria
Conclusions:
Based on the findings of the in vivo study with rabbits, the test substance is considered to be corrosive to the skin.