Registration Dossier
Registration Dossier
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EC number: 214-093-2 | CAS number: 1079-66-9
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1973
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Secondary information from a study in rats, performed in 1973, taken from public TSCA8e submission file. Study was neither performed according to guidelines nor to GLP. However, test parameters documented are sufficient to use the study data in a supporting manner, since they are well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was generated into a 32 liter positive pressure inhalation chamber by means of a Midget Impigner. The exposure was 1-hour and the test animals were observed for 14-days after exposure.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Chlorodiphenylphosphine
- EC Number:
- 214-093-2
- EC Name:
- Chlorodiphenylphosphine
- Cas Number:
- 1079-66-9
- Molecular formula:
- C12H10ClP
- IUPAC Name:
- diphenylphosphinous chloride
- Details on test material:
- clear colorless diphenyl phosphinous chloride
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Duration of exposure:
- 1 h
- Concentrations:
- 0.95 and 2.32 mg/l
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 2.32 mg/L air
- Exp. duration:
- 45 min
- Clinical signs:
- other: No apparent signs of toxicity were observed at the 0.95 mg/L test concentration. The 2.32 mg/L test concenration produced gasping, depressions, and mild eye irritation, subsiding upon removal from chamber.
- Gross pathology:
- All animals appeared normal when necropsied 14 days after exposure.
Any other information on results incl. tables
The concentration 2.32 mg/l had to be terminated at 45 minutes due to crystallization of the test material.
Applicant's summary and conclusion
- Conclusions:
- The LC50 was determined to be higher than 2.32 mg/L after an inhalative exposure of 45 min.
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