Chlorodiphenylphosphine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vivo

Type of information:

experimental study

Adequacy of study:

other information

Study period:

1973

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Secondary information from a study in rats, performed in 1973, taken from public TSCA8e submission file. Study was not performed according to GLP, but test parameters documented are sufficient to accept the data, which are well documented and scientifically acceptable.

Data source

Reference

Title:

Unnamed

Year:

1973

Report date:

1973

Materials and methods

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

The procedure employed is in accordance with the test for eye irritation outlined in the Code of Federal Regulations (Part 191.12, Chap. 1, Title 21) for evaluating hazardous substances.
The test material was placed in one of each animal by gently pulling the lower lid away from the eyeball. The other eye, remaining untreated, served as the control. Animals were observed at 24, 48, and 72 hours following treatment and scored for irritation properties.
Eye irritation was determined according to the method outlined in the "Illustrated Guide for Grading Eye Irritation by Hazardous Substances". A total score of 110 is possible. A non-irritant must have a score of 10 or less. If, at the end of 72 hours ocular damage appears to be remissible (reversible), the animal is observed for an additional 4-7 days before final scoring is possible.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

Chlorodiphenylphosphine

EC Number:

214-093-2

EC Name:

Chlorodiphenylphosphine

Cas Number:

1079-66-9

Molecular formula:

C12H10ClP

IUPAC Name:

diphenylphosphinous chloride

Details on test material:

clear colorless diphenyl phosphinous chloride

Test animals / tissue source

Species:

rabbit

Test system

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

100 mg or 0.1 mL

Duration of treatment / exposure:

up to 72 hours

Observation period (in vivo):

up to 4 to 7 days

Number of animals or in vitro replicates:

6

Results and discussion

In vivo

Results

Irritation parameter:

other: destruction of entire eye structure

Basis:

mean

Remarks:

animals 1-6

Time point:

24/48/72 h

Score:

4

Max. score:

4

Reversibility:

not reversible

Remarks on result:

not determinable

Any other information on results incl. tables

The test substance destroyed the entire eye structures in all six test animals.

Applicant's summary and conclusion

Interpretation of results:

Category 1 (irreversible effects on the eye) based on GHS criteria

Conclusions:

Based on the findings of the in vivo study with rabbits, the test substance is considered to be corrosive to the eyes.