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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

The information on acute toxicity is limited. The substance is highly reactive and releases hydrochloric acid upon contact with water. As such, it is corrosive.
oral: The oral LD50 in rats was calculated to be 316 mg/kg bw.
inhalative: The LC50 in rats was determined to be higher than 2.32 mg/L.
dermal: The dermal LD50 was determined to be greater than 2150 mg/kg bw after occulsive application to the skin of rabbits.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
316 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating conc.
Value:
2 320 mg/m³ air

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
adverse effect observed
Dose descriptor:
LD50
Value:
2 150 mg/kg bw

Additional information

oral:

Information available indicates, that no mortality occurs after a single oral exposure of 464 mg/kg bw in rats. Mortality in all animals was observed at doses of 464 mg/kg bw or higher. [Stauffer Chemical Company, 1973]

inhalative:

Information available indicates, that no mortality occurs upon an inhalative exposure of 2.32 mg/L in rats. [Stauffer Chemical Company, 1973]

dermal:

Information available indicates, that dermal exposure of 2150 mg/kg bw in rabbits caused one dead animal. Mortality was deduced to the corrosive potential of the test substance. [Stauffer Chemical Company, 1973]

The substance reacts upon contact with water and releases hydrochloric acid. Local effects are the most prominent effects for this substance.

 

Justification for classification or non-classification

Dangerous Substance Directive (67/548/EEC)

As a result of available information, the substance is considered to be classified for acute oral toxicity (Xn; R22) under Directive 67/548/EEC, as amended for the 28th time in Directive 2001/59/EC.

Classification, Labelling, and Packaging Regulation (EC) No. 1272/2008

As a result of available information, the substance is considered to be classified for acute oral toxicity (Acute class 4) under Regulation (EC) No. 1272/2008, as amended for the second time in Directive (EC 286/2011).