Registration Dossier
Registration Dossier
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EC number: 214-093-2 | CAS number: 1079-66-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: see 'Remark'
- Remarks:
- Secondary information from a study in rats, performed in 1973, taken from public TSCA8e submission file. Study was not performed according to GLP, but test parameters documented are sufficient to accept the data, which are well documented and scientifically acceptable.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 973
- Report date:
- 1973
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The test material was administered under a rubber dental damming sleeve; with the trunk of the animal then being wrapped with gauze. The exposure period was 24-hours. the observation period was 14 days.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Chlorodiphenylphosphine
- EC Number:
- 214-093-2
- EC Name:
- Chlorodiphenylphosphine
- Cas Number:
- 1079-66-9
- Molecular formula:
- C12H10ClP
- IUPAC Name:
- diphenylphosphinous chloride
- Details on test material:
- clear colorless diphenyl phosphinous chloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 2150 mg/kg
- No. of animals per sex per dose:
- 4
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- > 2 150 mg/kg bw
- Mortality:
- No signs of systemic toxicity were observed. One of four annimals died during the experiment. The fatality was due to the severe eschar caused by this corrosive compound.
Applicant's summary and conclusion
- Conclusions:
- The dermal LD50 was determined to be greater than 2150 mg/kg bw after occulsive application to the skin of rabbits.
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