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EC number: 273-179-8 | CAS number: 68952-95-4 A complex combination of fatty acids, neutral vegetable-oil, proteins, and other minor components produced by boiling vegetable-oil soapstock with mineral acid and, optionally, further separating the oil phase acidulated soapstock from the aqueous phase.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- From October 23, 1995 to December 1, 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 996
- Report date:
- 1996
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- A human repeat insult patch test was carried out on 88 volunteers. The substance was tested at a concentration of 50% v/v in liquid paraffin which was also included in the study as a control material. 24 h induction patches were applied 3 d/wk for 3 wks followed by challenge patch application after 14 d of rest. The test sites were scored before application of subsequent patches during the induction phase and 48 and 96 h after challenge application.
- GLP compliance:
- yes
Test material
- Reference substance name:
- Glycerides, C16-18 and C18-unsatd.
- IUPAC Name:
- Glycerides, C16-18 and C18-unsatd.
- Reference substance name:
- Glycerides, C16-18 and C18-unsatd.
- EC Number:
- 266-948-4
- EC Name:
- Glycerides, C16-18 and C18-unsatd.
- IUPAC Name:
- 266-948-4
- Reference substance name:
- 67701-30-8
- Cas Number:
- 67701-30-8
- IUPAC Name:
- 67701-30-8
- Details on test material:
- - Name of test material: Cremeol PS-17; which contains:
Partially hydrogenated soybean oil: 50% (CAS N° 8016-70-4, EC N° 232-410-2); under the SDA nomenclature, the name of this substance is ‘Glycerides, C16-18 and C18-unsatd.’
Partially hydrogenated palm oil: 50%
- Physical state: Light amber liquid
Constituent 1
Constituent 2
Constituent 3
Method
- Type of population:
- general
- Ethical approval:
- confirmed and informed consent free of coercion received
- Subjects:
- - Number of subjects exposed: 88
- Sex: Male/Female
- Age: > 18 yrs - Clinical history:
- No data
- Controls:
- Concurrent vehicle (Liquid Paraffin) applied to volunteers
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: Repeat insult patch test (epicutaneous test)
ADMINISTRATION
- Application site: Arm
- Description of patch: 2 cm X 2 cm square Werbil pads located down the center line of a piece of Blenderm tape. A patch with 3 Werbil squares comprised one patch strip.
- Vehicle/solvent: Liquid paraffin
- Concentrations: 50% v/v
- Volume applied: 0.3 mL
- Testing/scoring schedule: 24 h induction patches applied 3 d/wk for 3 wks followed by challenge patch application after 14 d of rest. The test sites were scored before application of subsequent patches during the induction phase and 48 and 96 h after challenge application.
EXAMINATIONS
- Grading/Scoring system:
0 No visible erythema
1 Mild erythema (faint pink to definite pink)
2 Moderate erythema (definte response)
3 Severe erythema (very intense redness)
Oedema, papules, vesicles and bullae, if present, are graded as independent responses.
Results and discussion
- Results of examinations:
- Induction: No skin irritation reactions during induction phase
Challenge: No evidence of skin sensitization at challenge
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- Based on the results, the substance was found to be non-sensitizing in human repeat insult patch test at concentration of 25%.
- Executive summary:
A human repeat insult patch test was carried out on 88 volunteers with ‘glycerides, C16-18 and C18-unsatd.’ (as Cremeol PS-17 containing partially hydrogenated soybean oil: 50%; partially hydrogenated palm oil: 50%). Cremeol PS-17 was tested at a concentration of 50% v/v in liquid paraffin (i.e. the concentration of partially hydrogenated soybean oil was 25%) which was also included in the study as a control material. 24 h induction patches were applied 3 d/wk for 3 wks followed by challenge patch application after 14 d of rest. The test sites were scored before application of subsequent patches during the induction phase and 48 and 96 h after challenge application. The substance neither produced irritation during the induction nor elicited reactions indicative of sensitization at challenge. Based on the results, the substance was found to be non-sensitizing in human repeat insult patch test at concentration of 25% (Cuthbert and Neilson, 1996).
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