Soaps, stocks, vegetable-oil, acidulated

Water solubility

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

water solubility

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Study period:

From 15 June, 2010 to 27 July, 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

KL2 due to RA

Justification for type of information:

Refer to the section 13 for details on the read across justification. The water solubility study with the read across substance is used as a supporting study.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

6.4 mg/L

Temp.:

20 °C

pH:

>= 4.7 - < 5.1

Details on results:

- Calibration range: 1 to 100 mg carbon/L pure water in the case of TC-calibration; 1 to 100 mg carbon/L pure water in the case of IC-calibration
- Regression coefficient (r²): At least 0.9999 in the case of TC; at least 0.9999 in the case of IC
- Typical calibration curve: y = 4.3503x + 0.5259 in the case of TC; y = 4.5231x + 0.7286 in the case of IC
- Limit of detection: LOD TC: 1.3334 mg carbon/L; LOD IC: 1.5224 mg carbon/L
- Limit of quantification: LOQ TC: 4.7352 mg carbon/L; LOQ IC: 5.4007 mg carbon/L
- LOQ Test item: 2 mg carbon/L corresponding to 2.6 mg test substance/L

None

Conclusions:

Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 6.4 mg/L at 20 ± 2°C.

Executive summary:

The water solubility of the read-across substance 'glycerides, C16-18 and C18-unsatd., deodorizer distillates' was determined using the shake flask method according to OECD Guideline 105 and EU Method A.6. The water solubility of read across substance was estimated to be higher than 0.01g/L in a preliminary test. Therefore, the flask method was used in the main test. The saturation mass concentration was estimated using TOC method. Under the conditions of the study, the water solubility of the substance was determined to be 6.4 mg/L at 20 ± 2°C (Mollandin, 2010c). Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 6.4 mg/L at 20 ± 2°C.

Reference 2

Endpoint:

water solubility

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Study period:

From 01 July, 2010 to 20 July, 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

KL2 due to RA

Justification for type of information:

Refer to the section 13 for details on the read across justification. The water solubility study with the read across substance is used as a supporting study.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

40 mg/L

Temp.:

20 °C

pH:

4.3

Details on results:

- Calibration range: 1 to 100 mg Carbon/L pure water in the case of TC-calibration; 1 to 100 mg carbon/L pure water in the case of IC-calibration
- Regression coefficient (r²): At least 1.000 in the case of TC; at least 0.9999 in the case of IC
- Typical calibration curve: y = 4.5706x + 0.4987 in the case of TC; y = 4.6248x - 0.2071 in the case of IC
- Limit of detection: LOD TC: 0.9498 mg carbon/L; LOD IC: 1.5941 mg carbon/L
- Limit of quantification: LOQ TC: 3.3824 mg carbon/L; LOQ IC: 5.6524 mg carbon/L
- LOQ Test item: 2 mg carbon/L corresponding to 2.8 mg test substance/L

None

Conclusions:

Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 40 mg/L at 20 ± 1°C.

Executive summary:

The water solubility of the read-across substance 'lauric fats deodorizer distillates' was determined using the shake flask method according to OECD Guideline 105 and EU Method A.6. The water solubility of read across substance was estimated to be higher than 0.01 g/L in a preliminary test (non-GLP). Therefore, the flask method was used in the main test. The saturation mass concentration of was estimated using TOC-method. Under the conditions of the study, the water solubility of the substance was determined to be 40 mg/L at 20 ± 1°C (Mollandin, 2010d). Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 40 mg/L at 20 ± 1°C.

Reference 3

Endpoint:

water solubility

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

key study

Study period:

From 23 April, 2010 to 20 July, 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

KL2 due to RA

Justification for type of information:

Refer to the section 13 for details on the read across justification. The water solubility study with the read across substance is used as a supporting study.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

31 mg/L

Temp.:

20 °C

pH:

>= 5.1 - < 5.5

Details on results:

- Calibration range: 1 to 100 mg carbon/L pure water in the case of TC-calibration; 1 to 100 mg carbon/L pure water in the case of IC-calibration
- Regression coefficient (r²): At least 1.0000 in the case of TC; at least 0.9999 in the case of IC
- Typical calibration curve: y = 4.5706x + 0.4987 in the case of TC; y = 4.6248x + 0.2071 in the case of IC
- Limit of detection: LOD TC: 0.9498 mg carbon/L; LOD IC: 1.5941 mg carbon/L
- Limit of quantification: LOQ TC: 3.3824 mg carbon/L; LOQ IC: 5.6524 mg carbon/L
- LOQ Test item: 2 mg C/L corresponding to 2.6 mg test item/L

None

Conclusions:

Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 31 mg/L at 20 ± 1°C.

Executive summary:

The water solubility of read across substance, 'oils, vegetable, deodorizer distillates' in water was determined according to OECD Guideline 105 and EU Method A.6. The water solubility of read across substance was estimated to be lower than 0.01 g/L in a preliminary test (non-GLP). Therefore, the column elution method was first selected for the main test. However, the column elution method was found to be not feasible and thus the flask method was finally used for the determination of the water solubility. The saturation mass concentration was estimated using the TOC method. Under the conditions of the study, the water solubility of read across substance was determined to be 31 mg/L at 20 ± 1°C (Mollandin, 2010a). Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 31 mg/L at 20 ± 1°C.

Reference 4

Endpoint:

water solubility

Type of information:

read-across based on grouping of substances (category approach)

Adequacy of study:

supporting study

Study period:

From 23 April, 2010 to 27 July, 2010

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

guideline study with acceptable restrictions

Remarks:

KL2 due to RA

Justification for type of information:

Refer to the section 13 for details on the read across justification. The water solubility study with the read across substance is used as a supporting study.

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

Principles of method if other than guideline:

Not applicable

GLP compliance:

yes (incl. QA statement)

Type of method:

flask method

Key result

Water solubility:

28 mg/L

Temp.:

20 °C

pH:

>= 5 - < 5.1

Details on results:

- Calibration range: 1 to 100 mg carbon/L pure water in the case of TC-calibration; 1 to 100 mg carbon/L pure water in the case of IC-calibration
- Regression coefficient (r²): At least 0.9999 in the case of TC; at least 0.9999 in the case of IC
- Typical calibration curve: y = 4.3503x + 0.5259 in the case of TC; y = 4.5231x + 0.7286 in the case of IC
- Limit of detection: LOD TC: 1.3334 mg carbon/L; LOD IC: 1.5224 mg carbon/L
- Limit of quantification: LOQ TC: 4.7352 mg carbon/L; LOQ IC: 5.4007 mg carbon/L
- LOQ Test item: 2 mg carbon/L corresponding to 2.5 mg test substance/L

None

Conclusions:

Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 28 mg/L at 20 ± 2°C

Executive summary:

The water solubility of the read-across substance 'soybean oil, deodorizer distillates' in water was determined according to OECD Guideline 105 and EU Method A.6. The water solubility of read across substance was estimated to be lower than 0.01 g/L in a preliminary test (non-GLP). Therefore, the column elution method was first selected for the main test. However, the column elution method was found not to be feasible and thus the flask method was finally used for the determination of the water solubility. The saturation mass concentration was estimated using the TOC method. Under the study conditions, the water solubility of the substance was determined to be 28 mg/L at 20 ± 2°C (Mollandin, 2010b). Based on the results of the read across study, the water solubility of the test substance, Soaps, stocks, vegetable oil, acidulated is considered to be 28 mg/L at 20 ± 2°C.

Description of key information

The water solubility of ‘Soaps, stocks, vegetable oil, acidulated’ was determined according to OECD Guideline 105 and EU Method A.6.

Key value for chemical safety assessment

Water solubility:

6.4 mg/L

at the temperature of:

20 °C

Additional information

Measured water solubility range was 6.4 to 40 mg/L.