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EC number: 212-855-9
CAS number: 873-94-9
Positive observations (6 volunteers):
This results suggests that sensory adaptation occurred during the first
exposure series at high concentrations and may be suggestive of local
anesthesia of receptors, which is a known phenomenon caused by exposure
to ketone vapors. Aside from this, no signifant differerences were noted
in subject sensory irritation response between the first and second
The irritating potential of dihydroisophorone was determined in an
investigation with 6 volunteers. After exposure for 7 minutes to 0.084,
0.117, 0.212, 0.393, and 0.549 mg/L (first exposure),
throat and nose irritation was reported at 0.117 mg/L and eye irritation
at 0.084 mg/L. The second exposure after two weeks led to throat, eye
and nose irritation at the lowest concentration tested (0.069 mg/L).
Dihydroisophorone is considered to be irritant to eyes and
respiratory system. A LOAEL of 0.069 mg/L was concluded for repeated
100 % odor detection of dihydroisophorone was found at 0.069 mg/L
at session 2.
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