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EC number: 212-855-9
CAS number: 873-94-9
RESULTS OF PILOT STUDY: None of the applied test substance concentrations caused primary skin irritation in any of the two
pilot studies 30 or 54 hours after administration.
RESULTS OF TEST
- Sensitization reaction: No signs of skin irritation were observed in the application areas of test and control animals 30 and 54 hours
- Clinical signs: No signs of systemic toxicity were observed.
1st, 2nd, and 3rd induction: No signs of skin irritation were observed in the application areas of test and control animals 30 hours
- Positive control: 3/10 test animals positive 30 hours after challenge, no control animal positive
- Other: The overall mean body weight increase of 227 g (test group) / 217 g (control group) is in the expected range: no treatment
The skin sensitizing properties of 3,3,5-trimethylcyclohexanone were
assessed in a buehler test according to OECD 406. Twenty female guinea
pigs were treated with 3 identical inductions on days 0, 7, and 14
(occlusive epicutaneous) of undiluted 3,3,5-trimethylcyclohexanone. Ten
control animals were similary treated, but with vehicle alone. Two weeks
after the induction treatment all animals were challegend with undiluted
substance and the vehicle. Under the conditions of this test the test
item 3,3,5-trimethylcyclohexanone showed no dermal sensitization in
female guinea pigs.
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