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EC number: 201-063-9
CAS number: 77-85-0
The “positive level” of ear swelling, which is 2x10-2 mm increase about
10% of the control values, has not been reached or exceeded in any dose
group. No substance specific effects were determined for ear weights
It has to be clarified that the “positive levels” mentioned above are
exclusively defined for the NMRI outbreed mice used for this study. Such
positive limits have to be calculated for each strain of mice
The body weights of the animals were not affected by any treatment
Trimethylolpropane was tested for sensitization potency using the
LLNA/IMDS assay in mice and applying concentrations between 2 and 50 %.
The results show that the test item Trimethylolpropane has no
sensitizing potential in mice after dermal application of up to and
including a concentration of 50%. No indication for a non-specific
(irritant) activation was detected, either. Therefore, the concentration
of 50% turned out to be the NOEL for the parameters investigated in this
study with respect to skin sensitization (Bayer 2010) .
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