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Diss Factsheets
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EC number: 201-063-9 | CAS number: 77-85-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study, GLP
- Justification for type of information:
- 1. HYPOTHESIS FOR THE ANALOGUE APPROACH
The read-across is an analogue approach based on the hypothesis that the Source substance (Trimethylolpropane (TMP)) and Target substance (Trimethylolethane (TME)) will have similar toxicological and ecotoxicological properties due to their close structural and physicochemical similarities.
The Source substance (which is registered at Annex X) has a comprehensive data set covering the REACH Annex VIII registration band at which the Target substance is being registered. The availability of this data set, along with the Source substances similarity to the Target substance, are considered sufficient for the read-across to be an appropriate adaptation to the standard information requirements of Annex VIII of the REACH regulation for the Target substance in accordance with the provisions of Annex XI, 1.5 of the REACH regulation.
2. SOURCE AND TARGET CHEMICAL(S) (INCLUDING INFORMATION ON PURITY AND IMPURITIES)
The Source substance is very pure (>99.6% w/w) while the technical grade of the Target substance as placed on the EU market contains two impurities; bis-TME (Cas No 63603-72-5) and Di-TME (Cas No 34541-79-2). The concentration of these impurities varies between batches and each impurity can be present at up to 4% w/w per batch.
The impurities in the Target substance are considered not to have any impact on toxicological or physico-chemical profile versus the main component. This is discussed further in the Read-Across Assessment Framework Report.
3. ANALOGUE APPROACH JUSTIFICATION
The Source and Target substances both contain the same 1,1,1-trimetholethyl group unit with the only structural difference being the presence of a methyl group (CH3-) for TMP instead of hydrogen (H-) for TME. Both the Source and Target substances have similar molecular weights of 134.17 and 120.15 respectively.
The physicochemical test results between the Source and Target substance are almost identical although water and logPow values are different as is the melting/freezing point. This divergence is not considered to have any significance to the read-across and is discussed further in the Read-Across Framework Report.
Because the structural and physicochemical profiles of the Source and Target substances are so similar, a read-across between the two substances is considered valid, as they are both expected to have similar toxicological and ecotoxicological profiles.
Further discussion of the similarities between the Source and Target substances is discussed in the Read-Across Assessment Framework Report.
4. DATA MATRIX
See Read-Across Assessment Framework Report - Parameter:
- % degradation (DOC removal)
- Value:
- 6
- Sampling time:
- 28 d
- Interpretation of results:
- not readily biodegradable
Reference
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Assessment is by read-across to the source substance trimethylolpropane (CAS No: 77-99-6).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.