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EC number: 201-063-9
CAS number: 77-85-0
There were no deaths or any abnormal clinical signs
attributable to the treatment in male und female rats of any
group throughout the dosing period. The body weights of both
males and females given 800 mg/kg were lower than those of
the control group during the premating period. Food
consumption revealed no differences between the control and
treated groups. There were no observed effects of the test
substance on hematological findings of the treated males.
Blood chemical examination revealed no changes indicating
any specific organ dysfunctions. Absolute and relative liver
weights were elevated significantly in male rats receiving
800 mg/kg and increased but not significantly, in female
rats receiving 800 mg/kg. Necropsy revealed hypertrophy of
the liver in 3 male rats receiving 800 mg/kg.
Histopathological examintion revealed no definite
morphological lesions. Slight basophilic alteration of the
renal tubular epithelial cells was observed in 1 female
receiving 50 mg/kg, in 2 females receiving 200 mg/kg and in
5 females receiving 800 mg/kg. These changes were not
unequivocally attributable to the test substance
administration, because of their limited distribution and
limited degree, and because similar lesions were observed in
male rats of all groups including the controls.
Trimethylolpropane was studied for oral toxicity in an OECD TG 422
(combined repeat dose and reproductive/ developmental toxicity screening
test) at doses of 0. 12.5, 50, 200, and 800 mg/kg bw/day given by
gavage. For repeat dose toxicity the NOAEL was achieved at 200 mg/kg
bw/day based on lowered body weight when compared to the controls, and
significantly increased absolute and relative liver weights in males and
elevated liver weights in females receiving 800 mg/kg bw/day with
histopathological changes which could not be unequivocally attributed to
treatment (MHLW 1994).
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