Ethylidynetrimethanol

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: The study is peer-reviewed in the SIDS, non-GLP study which satisfies the guideline requirements

Reason / purpose for cross-reference:

reference to same study

Reason / purpose for cross-reference:

reference to other study

Guideline:

other: Draft of the ASTM Comittee on Water quality: Proposed standard practice for conducting static acute toxicity tests on process wastewaters with Daphnia (1979) Draft 6, Personal correspondence.

GLP compliance:

no

Specific details on test material used for the study:

Details on properties of test surrogate or analogue material (migrated information):
Not applicable

Analytical monitoring:

not specified

Details on sampling:

Details not provided

Vehicle:

not specified

Details on test solutions:

Details not provided

Test organisms (species):

Daphnia magna

Details on test organisms:

Details not provided

Test type:

static

Water media type:

freshwater

Limit test:

no

Total exposure duration:

48 h

Post exposure observation period:

Details not provided

Hardness:

total hardness : 100 mg/L as CaCO3

Test temperature:

Details not provided

pH:

7.6

Dissolved oxygen:

Details not provided

Salinity:

Not applicable

Nominal and measured concentrations:

Nominal test substance concentrations: 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L

Details on test conditions:

- 4 replicates were tested
- 250 mL Erlenmayer flasks containing 200 mL of test solution and five 1 -3 day old daphnids

Reference substance (positive control):

not specified

Duration:

24 h

Dose descriptor:

EC50

Effect conc.:

14 500 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: immobility

Remarks on result:

other: 12,116 - 17,353 mg/L

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

13 000 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: immobility

Remarks on result:

other: 10,330 - 16,360 mg/L

Details on results:

Details were tot provided

Results with reference substance (positive control):

No data

Reported statistics and error estimates:

EC50 values were calculated by probit analysis.

No remarks

Validity criteria fulfilled:

not specified

Conclusions:

The 48-hour EC50 for trimethylolpropane was 13,000 mg/L.

Executive summary:

The 48-hr-acute toxicity of trimethylolpropane to Daphnia magna was studied under static conditions. Daphnids were exposed to the substance at nominal concentrations of 5,000; 7,500; 10,000; 15,000, 20,000, 25,000; 40,0000 mg/L. Immobilization was observed at 24 and 48h. The 48-hour EC50 was 13,000 mg/L (based on nominal concentrations).

This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.

Reference: Walton, J.R. and Davis, E.M., 1980

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

130 000 mg/L

Additional information

Assessment is by read-across to the source substance trimethylolpropane (CAS No: 77-99-6).