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EC number: 220-816-2
CAS number: 2906-12-9
The potential of 3-ISOPROPOXYPROPYLAMINE
to induce structural or numerical damage was evaluated in bone marrow
cells of mice. The study
was performed according to the international guidelines (OECD 474 and
Commission Directive No. B12) and in compliance with the principles of
Good Laboratory Practice. A preliminary toxicity test was
performed to define the dose-levels to be used for the cytogenetic study.
In the main study, three groups of five male and five female
Swiss Ico: OF1 (IOPS Caw) mice were given oral administrations of
3-ISOPROPOXYPROPYLAMINE at dose-levels of 125, 250 and 500 mg/kg/day,
over a 2-day period. One group of five males and five
females received the vehicle (water for injections) under the same
experimental conditions, and acted as control group. One
group of five males and five females received the positive control test
item (cyclophosphamide) once by oral route at the dose-level of
50 mg/kg/day. The animals of the treated and vehicle
control groups were killed 24 hours after the last treatment and the
animals of the positive control group were killed 24 hours after the
single treatment. Bone marrow smears were then prepared. For
each animal, the number of the micronucleated polychromatic erythrocytes
(MPE) was counted in 2000 polychromatic erythrocytes. The polychromatic
(PE) and normochromatic (NE) erythrocyte ratio was established by
scoring a total of 1000 erythrocytes (PE + NE).
In the two vehicle control groups, the
frequency of MPE as well as the PE/NE ratio were consistent with our
historical data. Cyclophosphamide
induced a significant increase (p < 0.01) in the frequency of MPE,
indicating the sensitivity of the test system under our experimental
conditions. The study was therefore considered as valid. In
all groups treated with 3-ISOPROPOXYPROPYLAMINE, the frequencies of MPE
were similar to those of their respective vehicle control groups, and no
statistically significant differences were observed. The PE/NE ratios
were not statistically significantly different from that of the
respective vehicle control groups. 3-ISOPROPOXYPROPYLAMINE
did not induce damage to the chromosomes or the mitotic apparatus of
mice bone marrow cells after two oral administrations, at a 24-hour
interval, at the dose-levels of 125, 250 and 500 mg/kg/day.
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