Registration Dossier

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

The delayed contact hypersensivity of 3-isopropoxypropylamine (IPOPA) was evaluated in Guinea pigs according a protocol similar to OECD N°406 guideline (Magnusson and Kligman test) (Manciaux, 1998b). The induction phase has been realized both by intradermal route on day 1 (IPOPA 0.1% in vehicle) and by cutaneous route on day 8 (IPOPA 25%) in 2 groups of guinea pigs: 5 males and 5 females for control group and 10 males and 10 females for treated group. The challenge phase was realized on day 22 by cutaneous application of IPOPA 10%; the cutaneous reactions were scored 24 and 48 hours after the challenge phase. No cutaneous reaction was observed in the animals of the control group. In the treated group, a very slight or well-defined erythema (grade 1 or 2) was noted at the 24hour reading in 6/20 and 13/20 guinea pigs respectively. A slight oedema (grade 2) was recorded in 3/20 animals. At the 48hour reading, a very slight or well-defined erythema (grade 1 or 2) persisted in 5/20 and 1/20 animals respectively. Dryness of the skin was observed in 14/20 animals and crusts were noted in one animal. 3-isoproxypropylamine induces delayed contact hypersensitivity in 65% and should be considered as a strong sensitizing.


Migrated from Short description of key information:
3-Isopropoxyproylamine induces delayed contact hypersensitivity in 65% and should be considered as a strong sensitiser.

Justification for selection of skin sensitisation endpoint:
Key study

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

- According to CLP criteria

Skin sensitizer category 1A, H317: May cause an allergic skin reaction

- According to DSD criteria

Xi, R43: May cause sensitisation by skin contact

Categories Display