Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 220-816-2
CAS number: 2906-12-9
The delayed contact hypersensivity of 3-isopropoxypropylamine
(IPOPA) was evaluated in Guinea pigs according a protocol similar to
OECD N°406 guideline (Magnusson and Kligman test) (Manciaux, 1998b). The
induction phase has been realized both by intradermal route on day 1
(IPOPA 0.1% in vehicle) and by cutaneous route on day 8 (IPOPA 25%) in 2
groups of guinea pigs: 5 males and 5 females for control group and 10
males and 10 females for treated group. The challenge phase was realized
on day 22 by cutaneous application of IPOPA 10%; the cutaneous reactions
were scored 24 and 48 hours after the challenge phase. No cutaneous
reaction was observed in the animals of the control group. In the
treated group, a very slight or well-defined erythema (grade 1 or 2) was
noted at the 24hour reading in 6/20 and 13/20 guinea pigs respectively.
A slight oedema (grade 2) was recorded in 3/20 animals. At the 48hour
reading, a very slight or well-defined erythema (grade 1 or 2) persisted
in 5/20 and 1/20 animals respectively. Dryness of the skin was observed
in 14/20 animals and crusts were noted in one animal.
3-isoproxypropylamine induces delayed contact hypersensitivity in 65%
and should be considered as a strong sensitizing.
- According to CLP criteria
Skin sensitizer category 1A, H317: May cause
an allergic skin reaction
- According to DSD criteria
Xi, R43: May cause sensitisation by skin
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again