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EC number: 220-816-2
CAS number: 2906-12-9
The acute dermal
irritation of 3-Isopropoxypropylamine (IPOPA) was evaluated in one male
New Zealand White rabbit according to OECD N° 404 Guideline. 0,5mL of
IPOPA was applied during 3minutes, 1hour and 4hours in the rabbit on
clipped area. The cutaneous reaction was observed one hour and then
daily to day 15 after removal of the dressing.
After application of
the substance during 3 minutes and 1 hour, a severe erythema (grade 4)
was observed from day1 to 11. It was masked by an important necrosis of
the skin thereafter. A severe oedema (grade4) was noted on day1.
Necrosis and thickening of the skin were recorded from day 1or 2, up to
the end of the observation period.
After a 4-hour
exposure, a severe erythema was observed from days 1 to 4. It was masked
by an important necrosis of the skin thereafter. Necrosis and thickening
of the skin were recorded from day 1, up to the end of the observation
experimental conditions, IPOPA has to be classified as corrosive.
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