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EC number: 220-816-2 | CAS number: 2906-12-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- end 1998-05-18
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1A: GLP, OECD 404 (1992 July 17th), EC 92/69 EEC B4 (1992 July 31st)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- : relative humidity sometimes out of the specified range. The 1-hour and 4-hour exposures of the test substance were spaced from 7days
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-isopropoxypropylamine
- EC Number:
- 220-816-2
- EC Name:
- 3-isopropoxypropylamine
- Cas Number:
- 2906-12-9
- Molecular formula:
- C6H15NO
- IUPAC Name:
- 3-(propan-2-yloxy)propan-1-amine
- Details on test material:
- - Name of test material (as cited in study report): 3-Isopropoxypropylamine
- Physical state: liquid
- Analytical purity: 99.78%
- Purity test date: 0997-08-07
- Lot/batch No.: 9708P0073
- Expiration date of the lot/batch: December 1998
- Stability under test conditions: no data
- Storage condition of test material: in dark at room temperature
- Other: orgin: Usine de Maurienne , La Chambre
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Elevage Cunicole de Val de Selle , 80160 Prouzel, France
- Age at study initiation: no data
- Weight at study initiation: 2362mg
- Housing: alone in a polystyrene cage (35x55x32cm or 48.2x58x36.5cm)
- Diet (e.g. ad libitum): ad libitum 112C pelleted diet (U.A.R. 91360 Villemoisson sur Orge, France)
- Water (e.g. ad libitum):ad libitum drinking water filtered by FG Millipore membrane (0.22µ)
- Acclimation period:at least 5days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18+/-3°C
- Humidity (%): 30-70%
- Air changes (per hr): approx. 12cycles
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated skin
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5mL
- Concentration (if solution): undiluted - Duration of treatment / exposure:
- 3min, 1h, 4h
- Observation period:
- 1, and then daily after removal of the dressing
- Number of animals:
- 1
- Details on study design:
- TEST SITE
- Area of exposure: 6cm²
- % coverage: -
- Type of wrap if used: gauze pad held in contact by an adhesive hypoallergenic aerated semi occlusive dressing
REMOVAL OF TEST SUBSTANCE
- Washing (if done):
- Time after start of exposure:
SCORING SYSTEM: according to the OECD 404guideline
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 48 hours
- Irritant / corrosive response data:
- Necrosis and thickness of the skin appeard at 24 hours and 48 hours respectively in the treated rabbit and persisted until the end of the study (14days).
Applicant's summary and conclusion
- Interpretation of results:
- Category 1A (corrosive)
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Under these experimental conditions, IPOPA is corrosive when applied to rabbits.
- Executive summary:
The acute dermal irritation of 3-Isopropoxypropylamine (IPOPA) was evaluated in one male New Zealand White rabbit according to OECD N° 404 Guideline. 0,5mL of IPOPA was applied during 3minutes, 1hour and 4hours in the rabbit on clipped area. The cutaneous reaction was observed one hour and then daily to day 15 after removal of the dressing.
After application of the substance during 3 minutes and 1 hour, a severe erythema (grade 4) was observed from day1 to 11. It was masked by an important necrosis of the skin thereafter. A severe oedema (grade4) was noted on day1. Necrosis and thickening of the skin were recorded from day 1or 2, up to the end of the observation period.
After a 4-hour exposure, a severe erythema was observed from days 1 to 4. It was masked by an important necrosis of the skin thereafter. Necrosis and thickening of the skin were recorded from day 1, up to the end of the observation period.
Under these experimental conditions, IPOPA has to be classified as corrosive.
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