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EC number: 220-816-2
CAS number: 2906-12-9
The Acute oral toxicity of 3-isopropoxypropylamine was evaluated
in male and female rats according to OECD N°401 guideline (Acute Toxic
Standard Method) (Manciaux, 1988). All animals died on day 1 after
administration of 2000 mg/kg. They showed hypoactivity, sedation,
piloerection, tremors, lateral recumbency and dyspnoea prior to death.
After administration of 1000 mg/kg, 2/5 rats showed sedation,
tonico-clonical convulsions and lateral recumbency prior to death on day
1. Theses clinical signs were less severe in surviving animals. At
500mg/kg, 1/5 animal showed sedation, piloerection and lateral
recumbency and then died on day 2. The oral LD50 of
3-isopropoxypropylamine was 909mg/kg (417-1755mg/kg) in female rats with
95% confidence interval limits.
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