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EC number: 220-816-2
CAS number: 2906-12-9
Results for the positive strain TA1535 with S9mix (direct
revertants per plate
The genotoxic activity of 3-isopropoxypropylamine was evaluated in
the Ames test onSalmonella typhimuriumaccording to the OECD 471
guideline (Haddouk, 1998). Doses from 156.25 to 5000µg/plate were tested
on five strains (TA 98, TA 100, TA 1535, TA 1537 and TA 102) in presence
or absence of metabolic activation. Two methods were used: direct plate
incorporation (1st experiment and 2nd experiment for TA 1535 only) and
preincubation 60 min at 37°C (2ndexperiment for all
strains except TA 1535) and the number of revertants colonies is
evaluated 48 to 72 hours later. The number of revertants of the vehicle
and positive controls was as specified in the acceptance criteria.
Without metabolic activation, the test substance did not induce any
significant increase in the number of revertants, in any of the 5
strains. With metabolic activation, an increase of the number of
revertant colonies was observed at the dose level of 2500 µg/plate for
the TA1535 strain (2.66-6.16 fold higher than control values). In
conclusion, 3-isopropoxypropylamine showed mutagenic activity in the
Ames test onSalmonella typhimuriumTA 1535 strain in the absence
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