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EC number: 220-816-2
CAS number: 2906-12-9
Scoring of skin reactions
S=dryness of the skin
The delayed contact hypersensivity of 3-isopropoxypropylamine
(IPOPA) was evaluated in Guinea pigs according a protocol similar to
OECD N°406 guideline (Magnusson and Kligman test) (Manciaux, 1998b). The
induction phase has been realized both by intradermal route on day 1
(IPOPA 0.1% in vehicle) and by cutaneous route on day 8 (IPOPA 25%) in 2
groups of guinea pigs: 5 males and 5 females for control group and 10
males and 10 females for treated group. The challenge phase was realized
on day 22 by cutaneous application of IPOPA 10%; the cutaneous reactions
were scored 24 and 48 hours after the challenge phase. No cutaneous
reaction was observed in the animals of the control group. In the
treated group, a very slight or well-defined erythema (grade 1 or 2) was
noted at the 24hour reading in 6/20 and 13/20 guinea pigs respectively.
A slight oedema (grade 2) was recorded in 3/20 animals. At the 48hour
reading, a very slight or well-defined erythema (grade 1 or 2) persisted
in 5/20 and 1/20 animals respectively. Dryness of the skin was observed
in 14/20 animals and crusts were noted in one animal.
3-isoproxypropylamine induces delayed contact hypersensitivity in 65%
and should be considered as a strong sensitiser.
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