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EC number: 220-816-2
CAS number: 2906-12-9
The inhalation of a highly
enriched/saturated vapor-air-mixture may represent a hazard (mortality
within 3 h). There is indication that the test substance causes local
irritation to exposed tissues (including respiratory tract).
In a test to demonstrate the toxicity of an atmosphere saturated
with vapours of the volatile components of isopropoxypropylamine at the
temperature chosen for vapour generation (20 °C) (BASF, 1970), 3 rats
per sex were exposed sequentially to the vapours, generated by bubbling
200 l/h air through a substance column of about 5 cm above a fritted
glass disc in a glass cylinder for 1 h, 3 h or 8 h. The documentation of
clinical signs was performed over a period of 7 days. During the 3 h
exposure, 1/6 animal died within 2 h of exposure and for the 8 h
exposure, 3/6 animals died within 4.5 h of exposure and 2/6 further
animals died within the end of exposure. Escape attempts, irritation of
the mucous membranes and dyspnoea were observed initially. After the 3
and 8 h exposure, convulsions, staggering, corrosion of eyes and noses
were also noted. 48 h post exposure in the 8 h exposure group
intermittent respiration, respiratory sounds and ruffled fur were noted.
All surviving animals gained weight. For the 8 h exposure, bloody nose
crusts, lungs filled with blood, corroded snouts, and sodden fur were
observed in 5 rats.
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