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EC number: 219-956-7
CAS number: 2582-30-1
No cytotoxicity indicated by either reduced relative cloning efficiency
1 (RCE1) or reduced
relative total growth (RTG) of below 20% of control was observed in both
The test substance was poorly soluble in culture medium. The highest
tested for gene mutations showed clear test substance precipitates in
Based on the results of the present study, the test substance did not
cause any biologically
relevant increase in the mutant frequencies either without S9 mix or
after adding a
metabolizing system in two experiments performed independently of each
Thus, under the experimental conditions described, Aminoguanidinium
carbonate did not induce forward mutations in vitro in the mouse
lymphoma assay with
L5178Y TK+/- cells in the absence and the presence of metabolic
The study is
classified as reliable without restriction. This study satisfies the
requirement for Test Guideline OECD 476 for in vitro mutagenicity
(mammalian forward gene mutation) data.
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