Registration Dossier
Registration Dossier
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EC number: 219-956-7 | CAS number: 2582-30-1
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: guideline used similiar to the guidelines of today
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: US Department of Health, Education and Welfare : Fed Reg 37 (83), 8535, 1972
- GLP compliance:
- no
Test material
- Reference substance name:
- Aminoguanidinium hydrogen carbonate
- EC Number:
- 219-956-7
- EC Name:
- Aminoguanidinium hydrogen carbonate
- Cas Number:
- 2582-30-1
- Molecular formula:
- CH6N4.CH2O3
- IUPAC Name:
- carbamimidoyldiazanium hydrogen carbonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- content: ca: 99 %
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 3-4 kg
- Housing: singly
- Diet ad libitum
- Water ad libitum
standard conditions
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- no details given
- Duration of treatment / exposure:
- 5 min or 24 hours
- Observation period (in vivo):
- 21 days
- Number of animals or in vitro replicates:
- 4 per exposure period
- Details on study design:
- According to the US Department of Health, Education and Welfare (Fed Reg 37 (83), 8535, 1972).
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 21 days
- Score:
- 0
- Remarks on result:
- other: exposure time 5 minutes
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 21 days
- Score:
- 0
- Remarks on result:
- other: exposure time 24 hours
- Irritant / corrosive response data:
- no irrtation are observed
Applicant's summary and conclusion
- Executive summary:
- Aminoguanidinium hydrogen carbonate was investigated for eye
irritating property in rabbits using a guideline given by the US
Department of Health, Education and Welfare (Fed Reg 37 (83), 8535, 1972).
Aminoguanidinium hydrogen carbonate was not irritating to the eyes of rabbits.
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