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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Subcutaneous application route is not relevant for humans.

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Histamine toxicity in mice and rats following treatement with histaminase inhibitors
Author:
Angelakos ET, Loew ER
Year:
1957
Bibliographic source:
Pharmacol Exp therapy 119, 444-451, 1957
Reference Type:
review article or handbook
Title:
Potential Health Hazards of Existing Chemicals: Aminoguanidine bicarbonate
Author:
Berufsgenossenschaft der Chemischen Industrie
Year:
1999
Bibliographic source:
Toxicological Evaluations 15, 417-431, Springer Verlag

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Single subcutaneous application and observation for clincal signs and mortality.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Aminoguanidinium hydrogen carbonate
EC Number:
219-956-7
EC Name:
Aminoguanidinium hydrogen carbonate
Cas Number:
2582-30-1
Molecular formula:
CH6N4.CH2O3
IUPAC Name:
N-aminoguanidine; carbonic acid
Test material form:
other: solid
Details on test material:
no further data

Test animals

Species:
other: rats and mice
Strain:
other: Wistar rats and Swiss mice
Sex:
not specified

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
not specified
Doses:
details not specified
No. of animals per sex per dose:
10 rats and 20 mice
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD50
Effect level:
2 314 mg/kg bw
95% CL:
>= 1 905 - <= 2 858
Remarks on result:
other: rat
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 770 mg/kg bw
95% CL:
>= 1 497 - <= 2 042
Remarks on result:
other: mouse

Applicant's summary and conclusion