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Additional toxicological data

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Administrative data

Endpoint:
additional toxicological information
Type of information:
other: secondary citation
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: secondary citation

Data source

Reference
Reference Type:
secondary source
Title:
Potential Health Hazards of Existing Chemicals: Aminoguanidine bicarbonate
Author:
Duffy PE, Defebdini R, Kremzner LT 1971 (cited in Toxicological Evaluations 15)
Year:
1999
Bibliographic source:
Toxicological Evaluations 15, 417-431, Springer Verlag

Materials and methods

Type of study / information:
in vitro investigation
Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
The incubation of menignoma cells with 10^(-4) M aminoguanidinium hydrogen carbonate caused an increase in the cell growth rate, changes in cell morphology and a change in growth pattern.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Aminoguanidinium hydrogen carbonate
EC Number:
219-956-7
EC Name:
Aminoguanidinium hydrogen carbonate
Cas Number:
2582-30-1
Molecular formula:
CH6N4.CH2O3
IUPAC Name:
N-aminoguanidine; carbonic acid
Test material form:
other: solid
Details on test material:
no details

Results and discussion

Any other information on results incl. tables

The incubation of menignoma cells with 10^(-4) M aminoguanidinium hydrogen carbonate caused an increase in the cell growth rate, changes in cell morphology and a change in growth pattern.

Applicant's summary and conclusion