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EC number: 219-956-7
CAS number: 2582-30-1
In a study which was carried out in accordance with OECD TG 407,
groups of 10 male and 10 female Wistar rats were given aminoguanidinium
hydrogen carbonate by gavage in doses of 100, 300, and 1000 mg/kg
bw/day. The controls were treated with a corresponding amount of the
vehicle (aqueous Cremphor suspension).
Administration of aminoguanidinium hydrogen carbonate did not lead
to increased mortality at any dose. In rats treated with 1000 mg/kg
bw/day there was isolated cased of salivation. Body weight gain was
decreased in males compared to controls which was in line with a
decrease in feed intake. The rats in this group also drank more water.
Apart from an increase in the activity of alkaline phosphatase in the
top dose, no treatment related effects were evident in clinical
chemistry and hematology tests and histopathological examination of the
rats treated with aminoguanidinium hydrogen carbonate.
The 300 mg/kg bw/day dose was thus tolerated without effects(NOEL)
under the conditions described (BG Chemie). The NOAEL is 1000 mg/kg
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