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EC number: 219-956-7
CAS number: 2582-30-1
The maximization test of Magnusson and Kligman was performed on
male guinea pigs to determine whether aminoguanidinium hydrogen
carbonate exhibits skin sensitization properties.
This GLP study was performed according to OECD Guideline No. 406.
The study was conducted with the following test concentrations.
intradermal induction: 5%
topical induction: 50 %
first challenge: 50 and 25 %
second challenge: 50 and 25 %
Aminoguanidinium hydrogen carbonate was formulated in sterile
physiological saline solution to yield a suspension.
After the first challenge the 50 % and 25% aminoguanidinium
hydrogen carbonate formulations led to skin redness in 20 % and 40 % of
the test animals respectively There were no skin reactions in the
After the second challenge the 50 % and 25 % aminoguanidinium
hydrogen carbonate formulations led to skin redness in 70 % and 45 % of
the test animals, respectively. There were no skin reactions in the
Aminoguanidinium hydrogen carbonate thus exhibits a definitive
skin-sensitization potential under the conditions of the maximization
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