Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 219-956-7 | CAS number: 2582-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- other: Expert statement
- Adequacy of study:
- key study
- Study period:
- 2015
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An extensive assessment of the toxicological behaviour of aminoguanidinium hydrogen bicarbonate was performed, taking into account the chemical structure, the available physico-chemical-data and the available (eco-)toxicological data.
Data source
Materials and methods
Test guideline
- Qualifier:
- no guideline required
Test material
- Reference substance name:
- Aminoguandinium hydrogen carbonate
- IUPAC Name:
- Aminoguandinium hydrogen carbonate
- Reference substance name:
- Aminoguanidinium hydrogen carbonate
- EC Number:
- 219-956-7
- EC Name:
- Aminoguanidinium hydrogen carbonate
- Cas Number:
- 2582-30-1
- Molecular formula:
- CH6N4.CH2O3
- IUPAC Name:
- carbamimidoyldiazanium hydrogen carbonate
- Details on test material:
- not applicable
Constituent 1
Constituent 2
- Radiolabelling:
- other: not applicable in this expert statement
Test animals
- Species:
- other: not applicable
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: all routes of administration are discussed in the expert statement
- Vehicle:
- other: not applicable
- Details on exposure:
- all routes of administration are discussed in the expert statement
- Details on study design:
- not applicable
- Details on dosing and sampling:
- not applicable
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- Based on physico-chemical properties which are not suggestive of significant absorption, absorption of the substance into the body is expected to be low via all exposure routes. No alerts were found for protein binding for the associated chemical or dissociated components.
- Details on distribution in tissues:
- For the target substance, the distribution is also expected to be limited as the absorption should be low. The compound can distribute to the tissues based on slight effects seen in the the liver, kidney, and thymus in a sub-acute study.
- Details on excretion:
- For the target substance no data is available concerning its elimination. It is believed that the test substance and any metabolites should be eliminated mainly via the urine or feces.
Metabolite characterisation studies
- Details on metabolites:
- If absorbed, the substance is expected to be metabolised by Phase I drugs metabolising enzymes with followed conjugation by Phase II reactions. It is expected that the substance may dissociate in vivo.
Any other information on results incl. tables
Background
There is data available on the physico-chemical properties of aminoguandinium hydrogen carbonate. The substance is as a solid that decomposes at approximately 172°C. Due to this decomposition, no boiling point or vapor pressure values could be determined. The LogKow was determined as -6.61 by calculation. The substance was shown not to be acutely toxic, the oral LD50 being above 5000 mg/kg bw and the dermal LD50 being greater than 5000 mg/kg bw. It has been shown to be neither a skin nor an eye irritant. Aminoguanidinium hydrogen carbonate was shown to bear a potential to cause allergic reactions. Repeated oral exposures during a reproductive study (OECD 421 study) revealed a NOAEL of 300 mg/kg bw/day for systemic effects and a LOAEL of 88 mg/kg bw/day for developmental toxicity. The NOAEL for reproductive toxicity was 1000 mg/kg bw/day.
Absorption, Metabolism, and Elimination
Absorption is expected to be limited based on low toxicity for systemic effects after acute and sub-acute exposures. Dermal adsorption is expected to be particularly low as the substance is neither corrosive nor irritating. In addition, inhalation absorption will also be low based on it being a solid.
Metabolism
The substance is likely to dissociate in the digestive tract. No protein binding alerts were found in OECD Toolbox for the chemical substance or the likely dissociated metabolites.
Elimination
Elimination is likely to be via the urine or feces.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
An extensive assessment of the toxicological behaviour of aminoguanidium hydrogen carbonate (expert statement), taking into account the chemical structure, the available physico-chemical-data and the available (eco-)toxicological data. - Executive summary:
Background
There is data available on the physico-chemical properties of aminoguandinium hydrogen carbonate. The substance is as a solid that decomposes at approximately 172°C. Due to this decomposition, no boiling point or vapor pressure values could be determined. The LogKow was determined as -6.61 by calculation. The substanc was shown not to be acutely toxic, the oral LD50 being above 5000 mg/kg bw and the dermal LD50 being greater than 2000 mg/kg bw. It has been shown to be neither a skin nor an eye irritant. Aminoguanidinium hydrogen carbonate was shown to bear a potential to cause allergic reactions. Repeated oral exposures as part of a reproductive study (OECD 421 study) revealed a NOAEL of 300 mg/kg bw/day for systemic effects and a LOAEL of 88 mg/kg bw/day for developmental toxicity. The NOAEL for reproductive toxicity was 1000 mg/kg bw/day.
Absorption, Metabolism, and Elimination
Absorption is expected to be limited based on low toxicity for systemic effects after acute and sub-acute exposures. Dermal adsorption is expected to be particularly low as the substance is neither corrosive nor irritating. In addition, inhalation absorption will also be low based on it being a solid.
Metabolism
The substance is likely to dissociate in the digestive tract. No protein binding alerts were found in OECD Toolbox for the chemical substance or the likely dissociated metabolites.
Elimination
Elimination is likely to be via the urine or feces.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.

EU Privacy Disclaimer
Tato webová stránka používá cookies, aby se vám naše stránky používaly co nejlépe.