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EC number: 219-956-7 | CAS number: 2582-30-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
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- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Hydrolysis
Administrative data
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 015
- Report date:
- 2015
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Aminoguanidinium hydrogen carbonate
- EC Number:
- 219-956-7
- EC Name:
- Aminoguanidinium hydrogen carbonate
- Cas Number:
- 2582-30-1
- Molecular formula:
- CH6N4.CH2O3
- IUPAC Name:
- carbamimidoyldiazanium hydrogen carbonate
- Reference substance name:
- Aminoguanidiniumhydrogencarbonat
- IUPAC Name:
- Aminoguanidiniumhydrogencarbonat
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report):Aminoguanidiuniumhydrogencarbonat
- Physical state: light yellowish powder
- Lot/batch No.: 120708
Constituent 1
Constituent 2
- Radiolabelling:
- no
Study design
- Analytical monitoring:
- yes
- Buffers:
- Buffer Solution pH 4.0 0.1 mol/L: 1.37 g potassium dihydrogen phosphate were dissolved in approx. 100 ml water. Phosphoric acid (85 %) was used to adjust the pH to 4.0. The concentration of the resulting solution was approx. 0.1 mol/L.
Buffer Solution PH 7.0 0.1 mol/L: 1.36 g potassium dihydrogen phosphate were dissolved in approx. 100 ml water. Sodium hydroxide solution (32 %) was used to adjust the pH to 7.0. The concentration of the resulting solution was approx. 0.1 mol/L.
Buffer Solution pH 9.0 0.1 molg/l: TIER 1: 3.82 g sodium tetraborate decahydrate were dissolved in approx. 100 ml water. Hydrochloric
acid (25 %) was used to adjust the pH to 9.0. The concentration of the resulting solution was approx. 0.1 mol/L.
TIER 2: 38.16 g sodium tetraborate decahydrate were dissolved in approx. 1000 ml water. Hydrochloric acid (25 %) was used to adjust the pH to 9.0. The concentration of the resulting solution was approx. 0.1 mol/L. - Details on test conditions:
- An alteration of the buffered test item solutions after sampling occurred because of the storage at approx. -20 °C in the first execution of the study. Furthermore, the number of sampling points in the initial phase of TIER 2 were insufficient to monitor the time dependent degradation Due to this issues, it was necessary to repeat the main study. Within the repetition , sampled solutions were analysed immediately and a sufficient number of sampling points was chosen. The performance and results of the repetition are presented in the following sections.
Stock solutions of the test item with a concentration of approx. 2.0 g/L were prepared by weighing the required test item amount into a volumetric flask and filling the flask to volume with Milli-Q water.
Buffer solutions (approx. 0.1 mol/L, pH 4, pH 7, and pH 9, see section 4.4) were used to retain the required pH value during the whole test period. Therefore, a buffered test item solution was prepared containing approx. 1.0 g/L (~approx . 0.007 mol/L) of the test item and approx. 0.05 mol/L buffer by mixing equal volumes of the test item stock solution (2.0 g/L) and buffer solution (approx. 0.1 mol/L). The pH value of each test item solution was verified by pH measurement with a pH-meter or suitable indicator strips. For the buffered test item solution at pH 4, additional pH adjustment with cone. hydrochloric acid was necessary. Supplementary, buffered blank solutions were prepared for each pH value by mixing equal volumes of buffer stock solution {approx. 0.1 mol/L) and Milli-Q water.
Referred to OECD 111 the test item was found to be unstable at pH 9 at 50 °C (degradation > 10 %; see section 5.1.2). Therefore, TIER 2 was performed at pH 9 for three different incubation temperatures (24.5 °C, 50 °C, and 70 °C).
Duration of testopen allclose all
- Duration:
- 5 d
- Temp.:
- 50 °C
- Number of replicates:
- Tier 1: 6
Tier 2: 4
Results and discussion
Dissipation DT50 of parent compoundopen allclose all
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- > 1 yr
- Type:
- (pseudo-)first order (= half-life)
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- ca. 1 yr
- Type:
- (pseudo-)first order (= half-life)
Any other information on results incl. tables
Final Data Tier 1
pH |
Temp. [°C] |
Duration [d] |
Degradation [%] |
4 |
50 |
5 |
3.4 |
7 |
50 |
5 |
2.8 |
9 |
50 |
5 |
11.5 |
In Tier 1 the test item was found to be hydrolytically stable at Ph 4 and pH 7. However, more than 10% degradation occurred in Tier 1 for pH9. Therefore, Tier 2 was performed at this pH value at 24.5 °C, 50 °C and 70 °C. The determined data suggests a pseudo first-order reation as the reaction mechanism for the hydrolysis under these conditions.
Hydrolysis Condition |
Half-Life of Test item at 25°C |
Acidic (pH 4) |
> 1 year |
Neutral (pH 7) |
> 1 year |
Basic (pH 9) |
Approx. 1 year |
Applicant's summary and conclusion
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