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Registration Dossier
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EC number: 219-956-7 | CAS number: 2582-30-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: simillar to guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- 10 male Wistar rats/ group received single doses of the test item by gavage and were observed for clinical signs and mortality for 14 days
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Aminoguanidinium hydrogen carbonate
- EC Number:
- 219-956-7
- EC Name:
- Aminoguanidinium hydrogen carbonate
- Cas Number:
- 2582-30-1
- Molecular formula:
- CH6N4.CH2O3
- IUPAC Name:
- carbamimidoyldiazanium hydrogen carbonate
- Test material form:
- other: solid
- Details on test material:
- content: ca. 99 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 180-200 g
- Housing: 5 per cage
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- 10 male Wistar rats/ group received single doses of aminoguanidinium hydrogen carbonate by gavage and were observed for clinical signs and mortality for 14 days.
- Doses:
- 3100, 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 males/group
- Control animals:
- no
- Details on study design:
- 10 male Wistar rats/ group received single doses of aminoguanidinium hydrogen carbonate by gavage and were observed for clinical signs and mortality for 14 days.
- Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Remarks on result:
- other: In the 5000 mg group 4/10 animals died: sedation and poor general condition
- Mortality:
- No animal died in the 3100 mg/kg bw group.
4/10 animals died within 2 to 6 days in the 5000 mg/kg bw group. - Clinical signs:
- other: 3100 mg/kg bw animals tolerated treatment without impairment 5000 mg/kg bw 10 /10: sedation, poor general condition
- Gross pathology:
- no details given
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information
- Executive summary:
Groups of 10 male Wistar rats received single oral doses (3100 or 5000 mg/kg bw) of aminoguanidinium hydrogen carbonate dissolved in water and were observed for 14 days. Rats dosed with 3100 mg/kg bw tolerated the treatment without clinical signs or mortality. All 10 rats dosed with 5000 mg/kg bw showed sedation and poor general condition within 2 to 6 days after application of aminoguanidinium hydrogen carbonate, 4/10 died. Thus the LD50(oral) is >5000 mg/kg bw.
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