Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Short description of key information:
In vitro, the substance reacts with DNA.
DNA damages are caused in various organisms, cells, and test systems e.g.
- Mutation is caused by the substance in bacteria and in plant cells.
- Mitotic recombination is caused by the substance in yeast.
- Chromosomal aberrations, sister chromatid exchanges and cell transformation are caused by the substance In cultured mammalian cells.
- DNA strand breaks are caused by the substance in vivo in rat brain cells.
(Based on data compiled by IARC 1999)

Endpoint Conclusion: Adverse effect observed (positive)

Justification for classification or non-classification

classification required (H350)