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Ecotoxicological information

Short-term toxicity to fish

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Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
(Q)SAR
Adequacy of study:
key study
Study period:
2011
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Calculation meeting relevant validity criteria e.g. scientific validity of (Q)SAR model established and applicable for substance, adequate results for risk assessment and classification, and adequate documentation provided.
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Cross-reference
Reason / purpose:
reference to same study

Data source

Reference
Reference Type:
other: QSAR
Title:
Unnamed
Year:
2011
Report Date:
2011

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: ECHA Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
Deviations:
no
Principles of method if other than guideline:
QSAR is the use of a mathematical model relating the reported parameter to the chemical structure (molecular descriptors) to yield a quantitative measure of this property. The predicted quantitative extend of the modeled property takes into account molecular parameters of group of the same and of similar substances (and - if available - of similar functional groups).
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
not reported

Sampling and analysis

Analytical monitoring:
not required

Test organisms

Test organisms (species):
other: Fish (freshwater and seawater)
Details on test organisms:
not required

Study design

Test type:
other: (Q)SAR
Limit test:
no
Total exposure duration:
96 h
Post exposure observation period:
not reported

Test conditions

Nominal and measured concentrations:
The results of the calculation are reported by the BIOWINTM in mmoles/L
Details on test conditions:
The OECD "ENVIRONMENT DIRECTORATE JOINT MEETING OF THE CHEMICALS COMMITTEE AND THE WORKING PARTY ON CHEMICALS, PESTICIDES AND BIOTECHNOLOGY", OECD SERIES ON TESTING AND ASSESSMENT 49 , uses the "Setubal principles" for assessment of the validity of a (Q)SAR which should (http://www.oecd.org/document/4/0,3746,en_2649_34379_42926724_1_1_1_1,00.html):
"1. be associated with a defined endpoint of regulatory importance
2. take the form of an unambiguous algorithm
3. ideally, have a mechanistic basis
4. be accompanied by a definition of domain of applicability
5. be associated with a measure of goodness-of–fit
6. be assessed in terms of its predictive power by using data not used in the development of the model"
(http://www.oecd.org/officialdocuments/displaydocumentpdf/?cote=env/jm/mono(2004)24&doclanguage=en). As the EPIWIN is a standard QSAR tool with decades long application in global scale, no further evaluation of the validity of the QSAR is required as long as the substance falls into applicability domain of the QSAR.
Reference substance (positive control):
not required

Results and discussion

Effect concentrations
Duration:
96 h
Dose descriptor:
LC50
Effect conc.:
334 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Remarks:
substance
Basis for effect:
mortality
Remarks:
substance
Remarks on result:
other: Freshwater

Any other information on results incl. tables

ECHA clarifies that "REACH Annex XI foresees the use of (Q)SARs and grouping methods when testing does not appear necessary because the same level of information can be obtained by means other than (vertebrate) testing." Annex XI of the REACH regulation reads:

"Results obtained from valid qualitative or quantitative structure-activity relationship models ((Q)SARs) may indicate the presence or absence of a certain dangerous property."

 

The calculation fulfills the following criteria of validity defined in the ECHA Guidance on information requirements and chemical safety assessment, Chapter R.6: QSARs and grouping of chemicals:

  • "results are derived from a (Q)SAR model whose scientific validity has been established": Model developed for and checked by EPA
  • "the substance falls within the applicability domain of the (Q)SAR model": organic substance with calculated result falling within data of test set
  • "results are adequate for the purpose of classification and labelling and/or risk assessment, and adequate and reliable documentation of the applied method is provided": Information is conclusive but does not indicate that the substance has to be classified in regard to the calculated parameter

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Information is conclusive but does not indicate that the substance has to be classified in regard to the calculated parameter
Executive summary:

The Estimation Programs Interface (EPI) Suite v4.10 (January, 2011) (EPIWEB 4.1) of the US Environmental Protection Agency supplies adequate information for environmental classification and labeling and no experimental testing is required