Registration Dossier
Registration Dossier
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EC number: 214-317-9 | CAS number: 1120-71-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data from peer-reviewed hadbook or collection of data. Reliable source (GESTIS)
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 009
Materials and methods
- Principles of method if other than guideline:
- According to Annex VII "Standard Information Requirements for Substances Manufactured or Imported in Quantities of one Tonne or More" of the "Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC” (as amended) (OJ L 396, 30.12.2006, p 1), 8.5, a study on acute toxicity is required under certain conditions. However, as the substance is classified and the acute toxicity an be assessed, (animal) testing is not required
- GLP compliance:
- not specified
- Test type:
- other: Assessment and expert judgement
- Limit test:
- no
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2-oxathiolane 2,2-dioxide
- Details on test material:
- Quelle : 02071
Toxicological Data, compiled by the National Institute of Health (NIH), USA, selected and distributed by Technical Database Services (TDS), New York, 2009
no other information available in the GESTIS: http://biade.itrust.de/biade/lpext.dll/Infobase/uberschrift43397?f=templates&fn=main-h.htm&2.0
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not reported
- Doses:
- no information available
- No. of animals per sex per dose:
- no information available
- Control animals:
- not specified
- Details on study design:
- no information available
- Statistics:
- no information available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 100 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: limited data base
Any other information on results incl. tables
Acute oral data retrieved from GESTIS (Gefahrstoff-Informations-System der Berufsgenossenschaften http://gestis.itrust.de)
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung
(IFA)
Division 1
Alte Heerstr. 111
53757 Sankt Augustin
Germany
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 oral rat 100 mg/kg
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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