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EC number: 214-317-9 | CAS number: 1120-71-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicity to soil macroorganisms except arthropods
Administrative data
- Endpoint:
- toxicity to soil macroorganisms except arthropods: short-term
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Calculation meeting relevant validity criteria e.g. scientific validity of (Q)SAR model established and applicable for substance, adequate results for risk assessment and classification, and adequate documentation provided.
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other: QSAR
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: ECHA Guidance on information requirements and chemical safety assessment Chapter R.6: QSARs and grouping of chemicals
- Deviations:
- yes
- Principles of method if other than guideline:
- QSAR is the use of a mathematical model relating the reported parameter to the chemical structure (molecular descriptors) to yield a quantitative measure of this property. The predicted quantitative extend of the modeled property takes into account molecular parameters of group of the same and of similar substances (and - if available - of similar functional groups).
- GLP compliance:
- no
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2-oxathiolane 2,2-dioxide
- Details on test material:
- not reported
Constituent 1
Sampling and analysis
- Analytical monitoring:
- not required
Test organisms
- Test organisms (species):
- other: earthworm (not otherwise specified)
- Animal group:
- annelids
Study design
- Study type:
- other: (Q)SAR
- Substrate type:
- not specified
- Limit test:
- no
- Total exposure duration:
- 14 d
Test conditions
- Details on test conditions:
- According to the ECHA Guidance on information requirements and chemical safety assessment, Chapter R.6: QSARs and grouping of chemicals, a QSAR calculation is valid as long as:
• "results are derived from a (Q)SAR model whose scientific validity has been established
• the substance falls within the applicability domain of the (Q)SAR model,
• results are adequate for the purpose of classification and labelling and/or risk assessment, and adequate and reliable documentation of the applied method is provided." - Reference substance (positive control):
- not specified
- Remarks:
- not required
Results and discussion
Effect concentrations
- Duration:
- 14 d
- Dose descriptor:
- LC50
- Effect conc.:
- 8 648 mg/kg soil dw
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Remarks:
- substance
- Basis for effect:
- mortality
Any other information on results incl. tables
- "results are derived from a (Q)SAR model whose scientific validity has been established": Model developed for and checked by EPA
- "the substance falls within the applicability domain of the (Q)SAR model": organic substance with calculated result falling within data of test set
- "results are adequate for the purpose of classification and labelling and/or risk assessment, and adequate and reliable documentation of the applied method is provided": Information is conclusive but does not indicate that the substance has to be classified in regard to the calculated parameter
ECHA clarifies that "REACH Annex XI foresees the use of (Q)SARs and grouping methods when testing does not appear necessary because the same level of information can be obtained by means other than (vertebrate) testing." Annex XI of the REACH regulation reads:
"Results obtained from valid qualitative or quantitative structure-activity relationship models ((Q)SARs) may indicate the presence or absence of a certain dangerous property."
The calculation fulfills the following criteria of validity defined in the ECHA Guidance on information requirements and chemical safety assessment, Chapter R.6: QSARs and grouping of chemicals:
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Not toxic to soil organisms
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
