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EC number: 214-317-9 | CAS number: 1120-71-4
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- genetic toxicity in vitro
- Remarks:
- Type of genotoxicity: other: several types, overall assessment
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given. Reliable source
Data source
Referenceopen allclose all
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 974
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 1 999
Materials and methods
- Principles of method if other than guideline:
- Several methods applied. Studies well documented. Studies meet generally accepted scientific principles. Studies acceptable for assessment
- GLP compliance:
- not specified
- Type of assay:
- other: literature compilation
Test material
- Reference substance name:
- 1,3-propanesultone
- EC Number:
- 214-317-9
- EC Name:
- 1,3-propanesultone
- Cas Number:
- 1120-71-4
- Molecular formula:
- C3H6O3S
- IUPAC Name:
- 1,2-oxathiolane 2,2-dioxide
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- other: In total 16 studies and several species and in vitro test systems
- Test concentrations with justification for top dose:
- several
Results and discussion
- Additional information on results:
- overwhelming evidence of genotoxicity
Any other information on results incl. tables
Approximately 2/3 of the following tests were positive:
· PRB, Prophage,umuinduction, SOS repair test, DNA strand breaks, cross-links or related damage
· Salmonella typhimuriumTA100, reverse mutation (9 tests)
· Saccharomyces cerevisiae, homozygosis by mitotic recombination or gene conversion
· Barley (Hordeum), mutation + NT 611
· Sister chromatid exchange, Chinese hamster lung fibroblasts in vitro
· Chromosomal aberrations, Chinese hamster lung fibroblasts in vitro
· Cell transformation, C3H 10T½ CL8 mouse cells in vitro
· Chromosomal aberrations, human lymphocytes in vitro
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
other: mostly positive
16 in vitro tests suggest that the substance has genetic toxicity - Executive summary:
genetoxic:
In vitro, the substance reacts with DNA.
DNA damages are caused in various organisms, cells, and test systems e.g.
- Mutation is caused by the substance in bacteria and in plant cells.
- Mitotic recombination is caused by the substance in yeast.
- Chromosomal aberrations, sister chromatid exchanges and cell transformation are caused by the substance In cultured mammalian cells.
- DNA strand breaks are caused by the substance in vivo in rat brain cells.
(Based on data compiled by IARC 1999)
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