Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- other: Case report
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Erythrocytic inclusion bodies in the blood of chemical workers
- Author:
- Hughes JP, Treon JF
- Year:
- 1 954
- Bibliographic source:
- Arch Ind Hyg Occup Med 10, 192-202 (1954)
Materials and methods
- Study type:
- poisoning incident
- Endpoint addressed:
- acute toxicity: dermal
- Principles of method if other than guideline:
- A chemical operator spilled a small amount of m-chloroaniline on his trousers.
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Test material form:
- other: liquid
- Details on test material:
- no data
Constituent 1
Method
- Subjects:
- 49-year old white chemical operator
- Route of exposure:
- dermal
- Reason of exposure:
- unintentional, occupational
- Exposure assessment:
- not specified
Results and discussion
- Clinical signs:
- About one hour later he became weak and lightheaded and was told by a fellow workman that his lips were blue. Four hours after the exposure, when cyanosis was most marked, 5% of the erythrocytes contained Heinz bodies. On the next day, after hospitalisation overnight and the administration of oxygen, slight cyanosis persisted. The percentage of red cells with Heinz bodies was now 18; on the third day it was 28, and on the seventh day 20. There was no anemia. The man returned to work on the fourth day after the exposure.
Any other information on results incl. tables
A 49-year old white chemical operator, in charging an autoclave spilled a small amount of m-chloroaniline on his trousers. About one hour later he became weak and lightheaded and was told by a fellow workman that his lips were blue. Four hours after the exposure, when cyanosis was most marked, 5% of the erythrocytes contained Heinz bodies. On the next day, after hospitalisation overnight and the administration of oxygen, slight cyanosis persisted. The percentage of red cells with Heinz bodies was now 18; on the third day it was 28, and on the seventh day 20. There was no anemia. The man returned to work on the fourth day after the exposure.
Applicant's summary and conclusion
- Executive summary:
A 49-year old white chemical operator, in charging an autoclave spilled a small amount of m-chloroaniline on his trousers. About one hour later he became weak and lightheaded and was told by a fellow workman that his lips were blue. Four hours after the exposure, when cyanosis was most marked, 5% of the erythrocytes contained Heinz bodies. On the next day, after hospitalisation overnight and the administration of oxygen, slight cyanosis persisted. The percentage of red cells with Heinz bodies was now 18; on the third day it was 28, and on the seventh day 20. There was no anemia. The man returned to work on the fourth day after the exposure.
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