Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study with acceptable restrictions.
Data source
Reference
- Reference Type:
- publication
- Title:
- #41: Short-term toxicity to fish
- Author:
- MITI
- Year:
- 2 000
- Bibliographic source:
- http://www.safe.nite.go.jp/jcheck/
- Report date:
- 2014
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Test material form:
- other: liquid
- Details on test material:
- - Purity
- Empirical formula: C6H6ClN
- Molecular mass: 127.58 g/mole
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Concentrations: 1.0, 1.8, 3.2, 5.6, 10, 18 and 32 mg/L plus control
Test solutions
- Vehicle:
- not specified
Test organisms
- Test organisms (species):
- Oryzias latipes
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
Test conditions
- Nominal and measured concentrations:
- Concentrations: 1.0, 1.8, 3.2, 5.6, 10, 18 and 32 mg/L plus control
- Details on test conditions:
- - Test volume: 3 L / Container
- Number of stations: 1 container / concentration group
- Number of test organisms: 10 fish / concentration group
- Temperature: 24 ± 1 ℃
- Lighting: 16 h light / 8 h dark
- Analysis: HPLC - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Duration:
- 96 h
- Dose descriptor:
- LC50
- Effect conc.:
- 8.79 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
- Remarks on result:
- other: 6.66 ~ 11.63 mg/L
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The acute toxicity to fish (Oryzias latipes) was tested under semi-static conditions. After 96 hours of exposure a LC50 of 8.79 mg/L was observed.
- Executive summary:
The acute toxicity to fish (Oryzias latipes) was tested under semi-static conditions. The study was concucted in accordance to the OECD guideline 203 "Fish, Acute Toxicity Test" (1992). The following nominal concentrations of 3-chloroaniline were tested: 1.0, 1.8, 3.2, 5.6, 10, 18 and 32 mg/L. After 96 hours of exposure a LC50 of 8.79 mg/L was determined.
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