3-chloroaniline

Dissociation constant

Administrative data

Endpoint:

dissociation constant

Type of information:

experimental study

Adequacy of study:

other information

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data from peer-reviewed handbook or collection of data.

Data source

Reference

Reference Type:

review article or handbook

Title:

Dissociation Constants of Organic Bases in Aqueous Solution

Author:

Perrin, D. D.

Year:

1965

Bibliographic source:

International Union of Pure and Applied Chemistry, UK

Materials and methods

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

3-chloroaniline

EC Number:

203-581-0

EC Name:

3-chloroaniline

Cas Number:

108-42-9

Molecular formula:

C6H6ClN

IUPAC Name:

3-chloroaniline

Test material form:

other: liquid

Details on test material:

- Purity not reported
- Empirical formula: C6H6ClN
- Molecular mass: 127.58 g/mole

Results and discussion

Any other information on results incl. tables

Results:

pK	Temperature [°C]	Remarks	Methods	Reference
3.46	25	C = 0.001, I = 0.02	O 5	Bryson, A., J. Am. Chem. Soc., 82, 4858 (1960)
3.67	25	c = 4x10^-5, pK of aniline taken as 4.57	O 5	Roberts, J. D et al.,  J. Am. Chem. Soc., 72, 408, (1950)
3.52	25	c = 4x 10^-4	O 5  with activity corrections	Biggs, A. I. et al., J. Chem. Soc., 1961, 388
3.60	25		O 5  with activity corrections	Biggs, A. I. et al., J. Chem. Soc., 1961, 2572
3.52	25
3.46	30
3.39	35
3.33	40
3.33	25	Few exp. details	O 2	Kilpatrick, M. and Arenberg, C. A., J. Chem. Soc., 75, 3812 (1953)
5.52	25	"Mixed" constant, I not stated	O 5	Vandenbelt, J. M. et al., Anal. Chem., 26, 726 (1954)
3.4	25	"Mixed" constant, I not stated	E3bg
3.46	25	I = 0.02 Other measurement: a, b	Partition	Williams, G. and Soper, F. G., J. Chem. Soc. 1930, 2469

c = concentration in mole/L

I = ½Σc_iz_i² = ionic strenght

O 5 =  Light absorption measurements combined with electrometric measurements

O 2 = Colorimetric determination with an indicator of known pK

E3bg = Measurements of pH changes during titrations using glass electrodes

Other measurement:

a = Brönsted, J. N. et al., Z. Physik. Chem. A169, 361 (1934)

b = Mason, S. F., J. Chem. Soc. 1954, 2071

Applicant's summary and conclusion

Conclusions:

The dissociation constant of 3-chloraniline was measured as a pK of 3.52 at 25 °C.

Executive summary:

The dissociation constant of 3-chloraniline was measured as a pK of 3.52 at 25 °C.