Registration Dossier
Registration Dossier
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EC number: 203-581-0 | CAS number: 108-42-9
Toxic effects on livestock and pets
Administrative data
- Endpoint:
- toxic effects on livestock and pets
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: review data
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- o-chloroaniline, m-chloroaniline BUA Report 57 (February 1991)
- Author:
- GDCh-Advisory committee on existing chemicals of environmental relevance (BUA)
- Year:
- 1 991
- Bibliographic source:
- S.Hirzel - Wissenschaftliche Verlagsgesellschaft Stuttgart
Materials and methods
- Principles of method if other than guideline:
- review
Test material
- Reference substance name:
- 3-chloroaniline
- EC Number:
- 203-581-0
- EC Name:
- 3-chloroaniline
- Cas Number:
- 108-42-9
- Molecular formula:
- C6H6ClN
- IUPAC Name:
- 3-chloroaniline
- Test material form:
- other: liquid
Constituent 1
Results and discussion
Any other information on results incl. tables
Regardless of the administration route, m-chloroaniline cause methemoglobin formation, which may vary in degree depending on the species. Oral, intraperitoneal or intravenous administration of m-chloroaniline to the cat, rat and dog led to methemoglobin levels similar to those caused by an equimolar aniline dose.
Applicant's summary and conclusion
- Executive summary:
Single and repeated administration of m-chloroaniline to cats, rats, mice and dogs lead to various degrees of methemoglobinemia and Heinz body formation, depending on the administration route and the dose.
The methemoglobin formation reaches its peak within the first 30 min to 5 hours after administration. With repeated exposure the acutely increased methemoglobin values in 2 of 4 studies returned to the normal range within a few weeks, even before the end of exposure.
In addition to methemoglobin formation, sulfhemoglobin formation was also described for rats exposed to m-chloroaniline by various administration routes. In other studies a single i.p. injection in mice lead to a slight increase in the sulfhemoglobin content of the blood; with a 3-day administration there was a more marked increase in the sulfhemoglobin values.
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