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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remark'
Remarks:
GLP Guideline study. According to the ECHA guidance document “Practical guide 6: How to report read-across and categories (Dec 2012)”, the reliability was changed from RL1 to RL2 to reflect the fact that this study was conducted on a read-across substance.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
no
GLP compliance:
yes
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Reference substance name:
Alcohols, C10-16, ethoxylated
EC Number:
500-182-6
EC Name:
Alcohols, C10-16, ethoxylated
Cas Number:
68002-97-1
IUPAC Name:
68002-97-1
Details on test material:
- Name of test material (as cited in study report): trade name- Ethoxylation degree: 2- Physical state: Slightly cloudy, colourless liquid- Analytical purity: 100% a.i. (info by sponsor)- Lot/batch No.: No data - Storage conditions of test material: Room temperature

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
According to Guideline.

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
unchanged (no vehicle)
Doses:
5050 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 5 050 mg/kg bw
Mortality:
No deaths occurred.
Clinical signs:
Clinical signs of toxicity included activity decrease, diarrhoea, piloerection and polyuria.
Body weight:
No effects.
Gross pathology:
No effects.

Applicant's summary and conclusion

Interpretation of results:
not classified
Remarks:
Migrated informationCriteria used for interpretation of results: EU

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