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Long-term toxicity to aquatic invertebrates

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Description of key information

EC20 (21d) = 2.83 mg/L for Daphnia magna reproduction (QSAR estimation)
The NOEC-values are not used for PNEC-calculation as a HC5-approach is performed on the basis of chronic tests available for several species of different trophic levels.

Key value for chemical safety assessment

Additional information

As no study is available for alcohol ethoxylate (C10-12, < 2.5 EO, CAS 67254-71-1), a read-across is prepared to a chronic invertebrate study conducted with a similar alcohol ethoxylate (C12-13, 6.5 EO). This 21 days flow-through chronic experiment on Daphnia magna is conducted according to the guidelines USEPA-TSCA (U.S. EPA, 1992) and ASTM (1988) and is well documented in the publication by Gillespie et al. (1999). The reported NOEC for reproduction is 0.77 mg/L.

Nevertheless the data allow not to derive a precise long-term effect value for the described mixture (C10-12, < 2.5 EO, CAS 67254-71-1). Alcohol ethoxylate specific QSARs were developed to describe the toxicity of varying mixtures (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006). The QSARs considered all three trophic levels (algae, invertebrates and fish). The effects are described as EC20 values, since the QSARs are more robust for the EC20 values than for NOEC or EC10 values (Boeije et al., 2006). For the described mixture (C10-12, < 2.5 EO, CAS 67254-71-1) the QSAR for long-term toxicity on reproduction of Daphnia magna (Boeije et al., 2006) results in an EC20 (21d, reproduction) of 2.83 mg/L. This result is used as key value for classification and labeling.