Alcohols, C10-12, ethoxylated

Long-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

long-term toxicity to aquatic invertebrates

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other:

Remarks:

Result derived from a (Q)SAR model with no adequate performance in internal validation, but the reliability and adequacy of the result is supported by similar substances from the model training set with experimental data. Thus the target prediction is in line with experimental data of the most similar substances and therefore the prediction is considered valid.

Justification for type of information:

1. SOFTWARE
Microsoft Excel, version 2016

2. MODEL (incl. version number)
DAPHNIA EC10 C/EO QSAR mass based toxic unit additivity

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Information on the compliance with the OECD criteria is provided in the attached QMRF.

5. APPLICABILITY DOMAIN
See information as provided in the attached QMRF and QPRF.

6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section and in the attached QPRF.

Qualifier:

according to guideline

Guideline:

other: REACH Guidance on QSARs and grouping of chemicals (R.6)

Principles of method if other than guideline:

QSAR mass based toxic unit additivity, see attached QMRF for details

GLP compliance:

no

Test organisms (species):

Daphnia magna

Test type:

other: (Q)SAR

Water media type:

freshwater

Total exposure duration:

21 d

Reference substance (positive control):

not required

Duration:

21 d

Dose descriptor:

EC10

Effect conc.:

0.312 mg/L

Conc. based on:

test mat.

Basis for effect:

reproduction

Description of key information

EC10 (21 d): 0.312 mg/L (C/EO QSAR mass based toxic unit additivity model)

Additional information

The assessment of the chronic toxicity of Alcohols, C10-12 (even numbered), ethoxylated (1-2.5 EO) to aquatic invertebrates is based on QSAR data derived from an AE substance specific QSAR model.QSAR models for alcohol ethoxylates were developed based on literature data (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006) and experimental results obtained for representative source substances. The descriptors used for the linear regression modeling are the number of carbon atoms in the main alkyl chain n (linear or branched) and the degree of ethoxylation m. Since the target substance is UVCB, a toxic unit approach is applied: the toxicity of a composition is calculated as a weighted average of the results obtained for single C(n)EO(m) units.

For the assessment of chronic toxicity of the target substance to aquatic invertebrates, an 21-d EC10 of 0.312 mg/L based on reproduction was predicted by an AE specificC/EO QSAR mass based toxic unit additivity model.