Alcohols, C10-12, ethoxylated

Toxicity to aquatic algae and cyanobacteria

Link to relevant study record(s)

Reference

Reference 1

Endpoint:

effects on growth of green algae

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

1. SOFTWARE
Microsoft Excel, version 2016

2. MODEL (incl. version number)
ALGAE ErC10 C/EO QSAR mass based toxic unit additivity

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Information on the compliance with the OECD criteria is provided in the attached QMRF.

5. APPLICABILITY DOMAIN
See information as provided in the attached QMRF and QPRF.

6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section and in the attached QPRF.

Qualifier:

according to guideline

Guideline:

other: REACH Guidance on QSARs and grouping of chemicals (R.6)

Principles of method if other than guideline:

QSAR mass based toxic unit additivity, see attached QMRF for details

GLP compliance:

no

Test organisms (species):

other: green algae

Test type:

other: (Q)SAR

Water media type:

freshwater

Total exposure duration:

72 h

Reference substance (positive control):

not required

Duration:

72 h

Dose descriptor:

EC10

Effect conc.:

0.498 mg/L

Conc. based on:

test mat.

Basis for effect:

growth rate

Reference 2

Endpoint:

effects on growth of green algae

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification

Justification for type of information:

1. SOFTWARE
Microsoft Excel, version 2016

2. MODEL (incl. version number)
ALGAE ErC50 C/EO QSAR mass based toxic unit additivity

3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”

4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Information on the compliance with the OECD criteria is provided in the attached QMRF.

5. APPLICABILITY DOMAIN
See information as provided in the attached QMRF and QPRF.

6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section and in the attached QPRF.

Qualifier:

according to guideline

Guideline:

other: REACH Guidance on QSARs and grouping of chemicals (R.6)

Principles of method if other than guideline:

QSAR mass based toxic unit additivity, see attached QMRF for details

GLP compliance:

no

Test organisms (species):

other: green algae

Test type:

other: (Q)SAR

Water media type:

freshwater

Total exposure duration:

72 h

Reference substance (positive control):

not required

Duration:

72 h

Dose descriptor:

EC50

Effect conc.:

0.919 mg/L

Conc. based on:

test mat.

Basis for effect:

growth rate

Description of key information

ECr50 (72 h): 0.919 mg/L (C/EO QSAR mass based toxic unit additivity model)

ErC10 (72 h): 0.498 mg/L (C/EO QSAR mass based toxic unit additivity model)

Additional information

The toxicity of Alcohols, C10-12 (even numbered), ethoxylated (1-2.5 EO) to aquatic algae was assessed in a weight of evidence approach based on the grouping of substances (category approach). The weight of evidence approach combines experimental data and data derived by AE substance specific QSAR calculations. The 72-h effect concentrations (ErC50), determined for the substances of the AE category, are in the range of range of 0.0311 - 14 mg/L based on algal growth (ErC10 (72 h): 0.0225 – 5.9 mg/L).

The assessment of the toxicity of Alcohols, C10-12 (even numbered), ethoxylated (1-2.5 EO) to aquatic algae is based on QSAR data derived from an AE substance specific QSAR model.QSAR models for alcohol ethoxylates were developed based on literature data (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006) and experimental results obtained for representative source substances. The descriptors used for the linear regression modeling are the number of carbon atoms in the main alkyl chain n (linear or branched) and the degree of ethoxylation m. Since the target substance is a UVCB, a toxic unit approach is applied: the toxicity of a composition is calculated as a weighted average of the results obtained for single C(n)EO(m) units.

For the assessment of toxicity of Alcohols, C10-12 (even numbered), ethoxylated (1-2.5 EO) to aquatic algae, a 72-h ECr50 of 0.919 mg/L was predicted by the AE specificC/EO QSAR mass based toxic unit additivity model (72-h ErC10: 0.498 mg/L).