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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 939-592-9 | CAS number: 67254-71-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- 1. SOFTWARE
Microsoft Excel, version 2016
2. MODEL (incl. version number)
DAPHNIA EC50 C/EO QSAR mass based toxic unit additivity
3. SMILES OR OTHER IDENTIFIERS USED AS INPUT FOR THE MODEL
See “Test material information”
4. SCIENTIFIC VALIDITY OF THE (Q)SAR MODEL
Information on the compliance with the OECD criteria is provided in the attached QMRF.
5. APPLICABILITY DOMAIN
See information as provided in the attached QMRF and QPRF.
6. ADEQUACY OF THE RESULT
See assessment of adequacy as outlined in the "Overall remarks, attachments" section and in the attached QPRF. - Qualifier:
- according to guideline
- Guideline:
- other: REACH Guidance on QSARs and grouping of chemicals (R.6)
- Principles of method if other than guideline:
- QSAR mass based toxic unit additivity, see attached QMRF for details
- GLP compliance:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- other: (Q)SAR
- Water media type:
- freshwater
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- not required
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 1.213 mg/L
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Reference
Description of key information
EC50 (48 h) 1.213 mg/L (C/EO QSAR mass based toxic unit additivity model)
Key value for chemical safety assessment
Additional information
The acute toxicity of Alcohols, C10-12 (even numbered), ethoxylated (1-2.5 EO) to aquatic invertebrates was assessed in a weight of evidence approach based on the grouping of substances (category approach). The weight of evidence approach combined experimental data and data derived by AE specific QSAR calculations. The effect concentrations (48-h EC50), determined for the AE category, are in the range of 0.125 – 40 mg/L.
The assessment of the acute toxicity of Alcohols, C10-12 (even numbered), ethoxylated (1-2.5 EO) to aquatic invertebrates is based on QSAR data derived from an AE substance specific QSAR model.QSAR models for alcohol ethoxylates were developed based on literature data (Wind & Belanger, 2006; Boeije et al., 2006; Belanger et al, 2006), and results obtained for representative source substances within the category. The descriptors used for the linear regression modelling are the number of carbon atoms in the main alkyl chain n (linear or branched) and the degree of ethoxylation m. Since the target substance is a UVCB, a toxic unit approach is applied: the toxicity of a composition is calculated as a weighted average of the results obtained for single C(n)EO(m) units.
For the assessment of acute toxicity of the target substance to aquatic invertebrates, an EC50 (48 h) of 1.213 mg/L was predicted using an AE specific C/EO QSAR mass based toxic unit additivity model.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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