2-phenoxyethyl acrylate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The study was conducted in compliance with Code of Federal Regulations, Title 16, Section 1500.41, and under GLP conditions

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1997

Report date:

1997

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: Code of Federal Regulations, Title 16, Section 1500.41

Principles of method if other than guideline:

NA

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

2-phenoxyethyl acrylate

EC Number:

256-360-6

EC Name:

2-phenoxyethyl acrylate

Cas Number:

48145-04-6

Molecular formula:

C11H12O3

IUPAC Name:

2-phenoxyethyl prop-2-enoate

Test material form:

liquid: viscous

Details on test material:

IRR169, clear pale yellow liquid, 100% monoethoxylated phenoxyethyl acrylate

Test animals

Species:

rabbit

Strain:

New Zealand White

Details on test animals or test system and environmental conditions:

Weight range beteen 2.4 and 4.0 kg bw, Age between 10 to 20 weeks. Housed individually in metal cages. Standard laboratory diet, SQC Rabbit Diet and drinking water ad libitum. Temperature 13.5-23 C, relative humidity 45-73%. Air exchange approximately 19 changes per hour. 12 hour artificial light from 0700 to 1900..

Test system

Type of coverage:

semiocclusive

Preparation of test site:

abraded

Vehicle:

unchanged (no vehicle)

Controls:

no

Amount / concentration applied:

0.5 ml was applied under 25*25mm gauze pads to one intact and one abraded skin site.

Duration of treatment / exposure:

24 hours

Observation period:

24 and 72 hours

Number of animals:

6.

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

24 h

Score:

>= 0.25

Reversibility:

fully reversible within: 72 hours

Irritant / corrosive response data:

At 24-hours reading very slight erythema with or without very slight oedema was seen at one intact and one abraded site. At 72-hour reading these reaction had resolved, and very slight erythema with or without very slight oedema was observed at another intact and abraded site.

Applicant's summary and conclusion

Interpretation of results:

slightly irritating

Remarks:

Migrated information Criteria used for interpretation of results: US CPSC / US FDA

Conclusions:

A single occlusive application of 2-phenoxyethyl acrylate to intact and abraded rabbit skin for 24 hours elicited very slight dermal irritation, primary irritation index was calculated to 0.25, and only two out of six animals showed dermal reactions. the substance should therefore not be classified as
irritating.

Executive summary:

The skin irritation potential of 2-phenoxyethyl acrylate was investigated on intact and abraded skin on rabbits. A single occlusive application for 24 hours elicited very slight dermal irritation, in two out of six animals. Primary irritation index was calculated to be 0.25. and 2-phenoxyethyl acrylate is therefore not a skin irritant. Hence, no classification is needed.