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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
two doses were used
Principles of method if other than guideline:
14 days acut toxicity study with one oral exposure, two doses 2150 and 5000 mg/kg.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-phenoxyethyl acrylate
EC Number:
256-360-6
EC Name:
2-phenoxyethyl acrylate
Cas Number:
48145-04-6
Molecular formula:
C11H12O3
IUPAC Name:
2-phenoxyethyl prop-2-enoate
Test material form:
other: liquid dissolved in olive oil

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
5 males and 5 females per concentration, approximately 12 weeks at start. At least one week acclimatization.
Food; SSNIFF R; FA.SSNIFF, Versuchstierdiaeten; 4470 Soest

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
olive oil
No. of animals per sex per dose:
5
Control animals:
no

Results and discussion

Effect levels
Sex:
female
Dose descriptor:
LD50
Effect level:
5 000 mg/kg bw
Based on:
test mat.
Mortality:
No mortality was observed
Clinical signs:
other: At highest dose, 5000 mg/kg bw; Dyspnea, staggering and overall bad condition were observed after one hour and untill 2 days. Shaggy fur was observed between 1 and 13 days. Apathy, anormalous behavior, signs of pain, spastic walking, redness of skin, dry

Applicant's summary and conclusion

Interpretation of results:
sligthly toxic
Remarks:
Migrated information
Conclusions:
No mortality were observed in any of the two doses tested. The acute LD50 value is therefore above 5000 mg/kg
Executive summary:

The acute toxicity of phenoxyethyl acrylate was tested in a single dose acute toxicity test, comparable to OECD Guideline 401. Two doses were tested 2150 and 5000 mg/kg. The substance was giving orally dissolved in olive oil, total volume was 5 and 10 ml/kg bw, which is acceptable according to the OECD guideline. Several clinical signs were observed, such as dyspnoea, shaggering, shaggy fur, redness of skin and hemi paralysis. The symptoms gradually ceased within hours to two days, except shaggy fur in the highest dose. No mortality was observed at any of the doses, therefore the acute LD50 value is above 5000 mg/kg.