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Administrative data

Link to relevant study record(s)

Description of key information

No toxicokinetic data is available.

As no specific data for the absorption rate from the oral, the dermal or the inhalational route of exposure is available, default assumption will be applied. Thus, absorption from the dermal and the oral route is considered to be the same. For extrapolation from orale exposure to inhalation exposure the absorption by inhalation is assumed to be a factor 2 higher.

Also, no data for the distribution, metabolism and elimination of 2 -phenoxyethyl acrylate is available. However, based on data from hydrolysis in water (OECD 111) and also considering potential activity from esterase cleavage of the molecule at its ether linkage, releasing of acrylic acid and 2 -phenoxyethanol can may be anticipated as suggested by NCI (see attached document). This may have further implication in the interpretation of the toxicity data.

Key value for chemical safety assessment

Bioaccumulation potential:
low bioaccumulation potential
Absorption rate - oral (%):
50
Absorption rate - dermal (%):
50
Absorption rate - inhalation (%):
100

Additional information

Based on the structure of 2-phenoxyethyl acrylate, no/low bioaccumulation is expected.