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EC number: 256-360-6
CAS number: 48145-04-6
A study was performed to determine the rate of hydrolysis of MIRAMER M140 as a function of pH. The test was conducted in accordance with the preliminary test as described in Commission Regulation (EC) No. 440/2008 (Method C.7) and the OECD Guidelines for Testing of Chemicals (Method 111).. The study was conducted in compliance with GLP.
A preliminary study showed that at pH 4 and 50 +/- 0.5ºC, less than 10%
hydrolysis had occurred after 5 days, equivalent to a half-life of
greater than 1 year under environmental conditions (25°C).
At each of pH 7 and 9 and 50 +/- 0.5ºC, more than 10% hydrolysis had
occurred after 5 days, equivalent to a half-life of less than 1 year
under environmental conditions (25°C).
MIRAMER M140 was determined to be hydrolytically stable under acidic
conditions, but unstable under neutral and basic conditions.
Estimation by SPARC using SMILES notation for the substance gave a hydrolytic
half-life =150 d at pH=7, which is
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