Registration Dossier
Registration Dossier
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EC number: 256-360-6 | CAS number: 48145-04-6
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Limit test:
- no
Test material
- Reference substance name:
- 2-phenoxyethyl acrylate
- EC Number:
- 256-360-6
- EC Name:
- 2-phenoxyethyl acrylate
- Cas Number:
- 48145-04-6
- Molecular formula:
- C11H12O3
- IUPAC Name:
- 2-phenoxyethyl prop-2-enoate
- Details on test material:
- Name of the test substance used in the study report: 2-Phenoxyethylacrylat
Purity: ca. 70%
Remaining acrylic acid < 1%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Acclimatization period: at least one week
Animal identification using cage cards (group identification).
Five animals per cage (type: stainless steel wire mesh cages).
Housing conditions: room temperature 20 - 26°C, relative humidity 45 - 75%, day/night rhythm 12 h / 12 h.
The animals were offered a standardized animal laboratory diet as well as tap water ad libitum. Food depreviation 16 hours before test substance application (water was available ad libitum).
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- olive oil
- Details on exposure:
- The test substance was insoluble in water.
Form of application: emulsion
Concentrations used: 4.3, 9.28 and 14% (w/v)
Application volume: 5 ml/kg - Doses:
- 215, 464 and 700 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 464 - < 700 mg/kg bw
- Mortality:
- 215 and 464 mg/kg: no deaths; 700 mg/kg: 10/10 after 14 days
- Clinical signs:
- Dyspnea, apathy, abnormal position, staggering, atony, paresis of the hindlimbs, missing cornea and pain reflexes, narcotic-like state, trembling, spastic gait, stretching, ruffled fur, erythema, exsiccosis, paresis, ptosis, cachexia, poor general state
- Body weight:
- Mean body weight male animals: 28.0 g at study start, 36.9 g after 13 days
Mean body weight female animals: 25.3 g at study start, 28.9 g after 13 days - Gross pathology:
- Animals that died: multiple intra-abdominal test substance residues
Sacrificed animals: no intra-abdominal test substance residues, no adherences
Applicant's summary and conclusion
- Executive summary:
464 mg/kg < LD50 by i.p. in mice < 700 mg/kg
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